MHC class II-deficient mice allow functional human CD4+ T cell development.
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DOI: 10.1002/eji.202250313
Abstract: Humanized mouse models have been developed to study cell-mediated immune responses to human pathogens in vivo. How immunocompetent human T cells are selected in a murine thymus in such humanized mice remains poorly explored. To… read more here.
Keywords: cell; mhc class; cd4; mice ... See more keywords