Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.
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DOI: 10.1016/j.chembiol.2019.08.008
Abstract: Rocaglates share a common cyclopenta[b]benzofuran core that inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase, eIF4A. Working as interfacial inhibitors, rocaglates stabilize the association between eIF4A and RNA, which can lead… read more here.
Keywords: potent class; eif4a; rocaglates potent; class eif4a ... See more keywords