Class I histone deacetylase inhibition promotes CD8 T cell activation in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3337
Abstract: Patients with epithelial ovarian cancer (EOC) typically present with late‐stage disease, posing a significant challenge to treatment. Although taxane and platinum‐based chemotherapy plus surgical debulking are initially effective, EOC is marked by frequent recurrence with… read more here.
Keywords: class histone; inhibition; ovarian cancer; cancer ... See more keywords
A class I histone deacetylase is implicated in the encystation of Entamoeba invadens.
Sign Up to like & getrecommendations! Published in 2020 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.05.014
Abstract: Epigenetic mechanisms such as histone acetylation and deacetylation participate in regulation of the genes involved in encystation of Entamoeba invadens. However, the histones and target residues involved, and whether the acetylation and deacetylation of the… read more here.
Keywords: encystation entamoeba; class histone; histone deacetylase; entamoeba invadens ... See more keywords
Targeting Class I Histone Deacetylases in a "Complex" Environment.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2016.12.006
Abstract: Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection, Alzheimer's disease, and Friedreich's ataxia. A problem with the currently available HDAC inhibitors is… read more here.
Keywords: deacetylases complex; class histone; complex environment; histone deacetylases ... See more keywords
Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c02179
Abstract: Class I histone deacetylase (HDAC) enzymes 1, 2, and 3 organize chromatin as the catalytic subunits within seven distinct multiprotein corepressor complexes and are established drug targets. We report optimization studies of benzamide-based Von Hippel–Lindau… read more here.
Keywords: class histone; hdac1 degradation; histone deacetylase; apoptosis ... See more keywords
Synthesis and biological evaluation of C-4 substituted phenoxazine-bearing hydroxamic acids with potent class II histone deacetylase inhibitory activities
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2212326
Abstract: Abstract Class II histone deacetylases (HDACs) are considered as potential targets to treat Alzheimer’s disease (AD). Previously, C-3 substituted phenothiazine-containing compounds with class II HDAC-inhibiting activities was found to promote neurite outgrowth. This study replaced… read more here.
Keywords: class; class histone; hdac; inhibitory activities ... See more keywords
A Novel Class of Histone Readers[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell"
DOI: 10.1105/tpc.18.00064
Abstract: Polycomb-group (PcG) proteins are part of an epigenetic memory system that regulates global gene expression throughout development in multicellular eukaryotes ([Butenko and Ohad, 2011][1]). Sophisticated mechanisms recruit high molecular weight complexes of PcG proteins to… read more here.
Keywords: class histone; readers open; novel class; histone readers ... See more keywords
Abstract 3181: Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3181
Abstract: Introduction: Recent evidence demonstrated that a low mutation rate seems a general feature of pediatric cancers. Ewing sarcoma (EwS) is defined by balanced chromosomal EWS/ETS translocations, which give rise to oncogenic chimeric proteins (EWS-ETS). Previously,… read more here.
Keywords: class; class histone; treatment; histone deacetylases ... See more keywords
Discovery of class I histone deacetylase inhibitors based on romidpesin with promising selectivity for cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0290
Abstract: Aim: Class I histone deacetylases (HDACs) are considered to be promising anticancer targets, but selective inhibition of class I HDAC isoforms remains a challenge. Methods & results: Previously, we obtained a selective class I HDAC… read more here.
Keywords: class; class histone; cancer cells; cancer ... See more keywords