Pathologic Diabetic Nephropathy in Autopsied Diabetic Cases With Normoalbuminuria From a Japanese Community-Based Study
Sign Up to like & getrecommendations! Published in 2021 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2021.09.007
Abstract: Introduction Albuminuria is a clinical hallmark of diabetic nephropathy (DN). Nevertheless, it is controversial whether pathologic DN lesions exist in individuals with diabetes with normoalbuminuria. We investigated the association between albuminuria levels and the frequency… read more here.
Keywords: class iia; uacr levels; glomerular lesions; diabetic cases ... See more keywords
High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02064
Abstract: We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an improved radiosynthesis of [18F]NT160 using… read more here.
Keywords: 18f nt160; class iia; pet imaging;
Scaffolding Activities of Pseudodeacetylase HDAC7.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical biology"
DOI: 10.1021/acschembio.4c00753
Abstract: Histone deacetylase (HDAC) enzymes remove acetyl groups from acetyllysine-containing proteins, including nucleosomal histones to control gene expression. Beyond fundamental cell biology, HDAC activity is linked to various cancers, with many HDAC inhibitors developed as anticancer… read more here.
Keywords: pseudodeacetylase hdac7; hdac; class iia; scaffolding activities ... See more keywords
Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21409
Abstract: Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages often have… read more here.
Keywords: class; inhibition; hdac; anti tumour ... See more keywords
Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11409-0
Abstract: The formation of new memories requires transcription. However, the mechanisms that limit signaling of relevant gene programs in space and time for precision of information coding remain poorly understood. We found that, during learning, the… read more here.
Keywords: class; experience dependent; iia hdacs; class iia ... See more keywords
Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27225-3
Abstract: The antimicrobial peptide pediocin PA-1 is a class IIa bacteriocin that inhibits several clinically relevant pathogens including Listeria spp. Here we report the synthesis and characterization of whole pediocin PA-1 and novel analogs thereof using… read more here.
Keywords: pediocin; analogs thereof; bacteriocin; iia bacteriocin ... See more keywords
Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab096
Abstract: Abstract In mammalian cloning by somatic cell nuclear transfer (SCNT), the treatment of reconstructed embryos with histone deacetylase (HDAC) inhibitors improves efficiency. So far, most of those used for SCNT are hydroxamic acid derivatives—such as… read more here.
Keywords: class; chlamydocin analogues; class iia; scnt ... See more keywords
A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritis
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Pharmacology"
DOI: 10.1111/bph.17306
Abstract: Most inhibitors of histone deacetylases (HDACs) are not selective and are cytotoxic. Some have anti‐inflammatory activity in disease models, but cytotoxicity prevents long‐term uses in non‐fatal diseases. Inhibitors selective for class IIa HDACs are much… read more here.
Keywords: novel inhibitor; class iia; inhibitor class; histone deacetylases ... See more keywords
Manganese Privation-Induced Transcriptional Upregulation of the Class IIa Bacteriocin Plantaricin 423 in Lactobacillus plantarum Strain 423
Sign Up to like & getrecommendations! Published in 2021 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00976-21
Abstract: Lactic acid bacteria hold huge industrial application and economic value, especially bacteriocinogenic strains, which further aids in the exclusion of specific foodborne pathogens. Since bacteriocinogenic strains are sought after, it is equally important to understand… read more here.
Keywords: class iia; plantaricin 423; class; iia bacteriocin ... See more keywords
Mining and Statistical Modeling of Natural and Variant Class IIa Bacteriocins Elucidate Activity and Selectivity Profiles across Species
Sign Up to like & getrecommendations! Published in 2020 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01646-20
Abstract: Class IIa bacteriocin antimicrobial peptides (AMPs), an alternative to traditional small-molecule antibiotics, are capable of selective activity toward various Gram-positive bacteria, limiting negative side effects associated with broad-spectrum activity. This selective activity is achieved through… read more here.
Keywords: class iia; activity toward; iia bacteriocins; activity ... See more keywords
Epigenomic mechanisms of alcohol-induced impaired differentiation of skeletal muscle stem cells; role of Class IIA histone deacetylases.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00043.2019
Abstract: Loss of functional metabolic muscle mass remains a strong and consistent predictor of mortality among people living with HIV (PLWH). PLWH have a higher incidence of alcohol use disorder (AUD), and myopathy is a significant… read more here.
Keywords: muscle; expression; differentiation; class iia ... See more keywords