First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53
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DOI: 10.1021/acs.jmedchem.1c00605
Abstract: MINA53 is a JmjC domain 2-oxoglutarate-dependent oxygenase that catalyzes ribosomal hydroxylation and is a target of the oncogenic transcription factor c-MYC. Despite its anticancer target potential, no small-molecule MINA53 inhibitors are reported. Using ribosomal substrate… read more here.
Keywords: class inhibitors; mina53; oxygenase; first class ... See more keywords
Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa539
Abstract: Abstract Translational frameshift errors are often deleterious to the synthesis of functional proteins and could therefore be promoted therapeutically to kill bacteria. TrmD (tRNA-(N(1)G37) methyltransferase) is an essential tRNA modification enzyme in bacteria that prevents… read more here.
Keywords: new class; class inhibitors; class; fragment based ... See more keywords