Detailed investigation of catalytically important residues of class A β-lactamase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2021.2023645
Abstract: Abstract An increasing global health challenge is antimicrobial resistance. Bacterial infections are often treated by using β-lactam antibiotics. But several resistance mechanisms have evolved in clinically mutated bacteria, which results in resistance against such antibiotics.… read more here.
Keywords: lactamase enzymes; class lactamase; resistance; lactamase ... See more keywords
Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa
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DOI: 10.1128/aac.01375-19
Abstract: Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare… read more here.
Keywords: strains pseudomonas; class lactamase; sequence type; lactamase pac ... See more keywords
In vivo functional analysis of a class A β-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus
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DOI: 10.1371/journal.pone.0215960
Abstract: In Streptomyces clavuligerus, the gene cluster involved in the biosynthesis of the clinically used β-lactamase inhibitor clavulanic acid contains a gene (orf12 or cpe) encoding a protein with a C-terminal class A β-lactamase-like domain. The… read more here.
Keywords: streptomyces clavuligerus; biosynthesis; clavulanic acid; acid ... See more keywords
In vitro and in vivo Inhibitory Activity of NADPH Against the AmpC BER Class C β-Lactamase
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2018.00441
Abstract: β-Lactamase-mediated resistance to β-lactam antibiotics has been significantly threatening the efficacy of these clinically important antibacterial drugs. Although some β-lactamase inhibitors are prescribed in combination with β-lactam antibiotics to overcome this resistance, the emergence of… read more here.
Keywords: ampc ber; ber; lactamase; activity ... See more keywords