Strategies for the measurements of expression levels and half-lives of HLA class I allotypes.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2019.02.001
Abstract: HLA class I molecules are highly polymorphic cell surface proteins that trigger immune responses by CD8+ T cells and natural killer (NK) cells. Most humans express six different HLA class I proteins encoded by the… read more here.
Keywords: class; expression levels; class molecules; hla class ... See more keywords
IFN&ggr; enhances cytotoxic efficiency of the cytotoxic T lymphocytes against human glioma cells
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.04.003
Abstract: Abstract Cytotoxic T lymphocytes (CTLs) are a key player in cancer immunotherapies, and MHC class I molecules on the cell surface are crucial for cellular recognition. However, the aberrant expression of MHC class I molecules… read more here.
Keywords: glioma; class molecules; glioma cells; ifn ggr ... See more keywords
Phosphosite-dependent presentation of dual phosphorylated peptides by MHC class I molecules
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104013
Abstract: Summary Phosphopeptides presented by major histocompatibility complex (MHC) class I have been regarded as a pivotal type of cancer neoantigens that are recognized by T cells. The structural basis of single-phosphorylated peptide presentation has been… read more here.
Keywords: mhc class; class molecules; presentation; phosphorylated peptides ... See more keywords
B-cell-specific accumulation of inclusion bodies loaded with HLA class II molecules in patients with mucolipidosis II (I-cell disease)
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Research"
DOI: 10.1038/s41390-018-0234-2
Abstract: BackgroundI-cell disease is characterized by the presence of vacuole-like inclusions in lymphocytes. However, the nature and clinical significance of these inclusions have seldom been characterized. In this study, the authors tried to elucidate the distribution… read more here.
Keywords: class molecules; cell; cell disease; hla class ... See more keywords
The new W family reconstructs the evolution of MHC genes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122079119
Abstract: The importance of adaptive immunity has been highlighted by the protection afforded by vaccination in the face of the current coronavirus pandemic. Much has been learned about the origins and subsequent evolution of the antigen-specific… read more here.
Keywords: mhc molecules; evolution mhc; class; class molecules ... See more keywords
Presence of antibodies against HLA class I and class II molecules in children before and after allo‐HSCT. Alloantibodies before and after HSCT
Sign Up to like & getrecommendations! Published in 2022 at "HLA"
DOI: 10.1111/tan.14817
Abstract: A severe complication of allogeneic hematopoietic stem cell transplantation (HSCT) is graft failure (GF). Among others, donor‐specific anti‐HLA antibodies (DSA) are associated with graft rejection after allogeneic or haploidentical transplantation in adults. Knowledge of DSA… read more here.
Keywords: hsct; hla class; class molecules; presence ... See more keywords
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj9867
Abstract: Specific MHC class II alleles are strongly associated with susceptibility to various autoimmune diseases. Although the primary function of MHC class II molecules is to present peptides to helper T cells, MHC class II molecules… read more here.
Keywords: mhc class; class molecules; class; complexed mhc ... See more keywords
MHC Class I Molecules Exacerbate Viral Infection by Disrupting Type I Interferon Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/5370706
Abstract: MHC class I molecules are key in the presentation of antigen and initiation of adaptive CD8+ T cell responses. In addition to its classical activity, MHC I may possess nonclassical functions. We have previously identified… read more here.
Keywords: viral infection; class molecules; mhc class; mhc ... See more keywords
A Missing Switch in Peptide Exchange for MHC Class II Molecules
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02513
Abstract: Antigen processing and loading of peptides onto MHC class II molecules is a multistep process that involves vesicular transport of the MHCII molecules along the secretory pathway, where they eventually merge with antigen-containing endocytic vesicles… read more here.
Keywords: switch; peptide exchange; class molecules; antigen ... See more keywords
From Chickens to Humans: The Importance of Peptide Repertoires for MHC Class I Alleles
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.601089
Abstract: In humans, killer immunoglobulin-like receptors (KIRs), expressed on natural killer (NK) and thymus-derived (T) cells, and their ligands, primarily the classical class I molecules of the major histocompatibility complex (MHC) expressed on nearly all cells,… read more here.
Keywords: chickens humans; class alleles; class; humans importance ... See more keywords
New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.886672
Abstract: The functions of a wide variety of molecules with structures similar to the classical class I and class II molecules encoded by the major histocompatibility complex (MHC) have been studied by biochemical and structural studies… read more here.
Keywords: mhc molecules; mhc; class molecules; present peptides ... See more keywords