A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.12.030
Abstract: In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI50 ranging 0.05-0.98 μM) and… read more here.
Keywords: class novel; tubulin polymerization; tubulin; compound e24 ... See more keywords
A class of novel 2T2R and 3T2R parallel mechanisms with large decoupled output rotational angles
Sign Up to like & getrecommendations! Published in 2017 at "Mechanism and Machine Theory"
DOI: 10.1016/j.mechmachtheory.2017.04.003
Abstract: Abstract This article focuses on the synthesis and analysis of a class of novel 2T2R (T denotes Translation and R denotes Rotation) and 3T2R parallel mechanisms (PMs) with large decoupled output rotational angles. Two articulated… read more here.
Keywords: 3t2r parallel; decoupled output; novel 2t2r; parallel mechanisms ... See more keywords
A Class of Novel Tetrahedron Elements with Curved Surfaces for Three-Dimensional Solid Mechanics Problems with Curved Boundaries
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Computational Methods"
DOI: 10.1142/s0219876219500063
Abstract: Linear tetrahedral elements with four nodes (Te4) are currently the simplest and most widely used ones in the finite element (FE) developed for solving three-dimensional (3D) mechanics problems. Ho... read more here.
Keywords: mechanics problems; novel tetrahedron; tetrahedron elements; three dimensional ... See more keywords