A DNA nicking Class 1 OLD family nuclease mediates phage defense in Vibrio cholerae and is countered by a phage-encoded inhibitor
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DOI: 10.1093/nar/gkaf728
Abstract: Abstract Bacteria are constantly threatened by their viral predators (phages), which has resulted in the development of defense systems for bacterial survival. One family of defense systems found widely across bacteria are OLD (for overcoming… read more here.
Keywords: old family; family nuclease; phage; family ... See more keywords
Structural characterization of Class 2 OLD family nucleases supports a two-metal catalysis mechanism for cleavage
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DOI: 10.1093/nar/gkz703
Abstract: Abstract Overcoming lysogenization defect (OLD) proteins constitute a family of uncharacterized nucleases present in bacteria, archaea, and some viruses. These enzymes contain an N-terminal ATPase domain and a C-terminal Toprim domain common amongst replication, recombination,… read more here.
Keywords: mechanism; class old; two metal; family ... See more keywords