The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.07.001
Abstract: S14161 is a pan-Class I PI3K inhibitor that induces blood cancer cell death, but its mechanism is largely unknown. In the present study, we evaluated the role of S14161 in autophagy, an emerging event in… read more here.
Keywords: s14161; pi3k inhibitor; beclin; class pi3k ... See more keywords
Emerging roles of class I PI3K inhibitors in modulating tumor microenvironment and immunity.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00500-8
Abstract: Immune system-mediated tumor killing has revolutionized anti-tumor therapies, providing long-term and durable responses in some patients. The phosphoinositide 3-kinase (PI3K) pathway controls multiple biological processes and is frequently dysregulated in malignancies. Enormous efforts have been… read more here.
Keywords: microenvironment; pi3k; pi3k inhibitors; class pi3k ... See more keywords
Class IA PI3K regulatory subunits: p110-independent roles and structures
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Society Transactions"
DOI: 10.1042/bst20190845
Abstract: The phosphatidylinositol 3-kinase (PI3K) pathway is a critical regulator of many cellular processes including cell survival, growth, proliferation and motility. Not surprisingly therefore, the PI3K pathway is one of the most frequently mutated pathways in… read more here.
Keywords: regulatory subunits; p110 independent; pi3k regulatory; class pi3k ... See more keywords