Robust immunoglobulin class switch recombination and end joining in Parp9‐deficient mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646757
Abstract: To mount highly specific and adapted immune responses, B lymphocytes assemble and diversify their antibody repertoire through mechanisms involving the formation of programmed DNA damage. Immunoglobulin class switch recombination (CSR) is triggered by DNA lesions… read more here.
Keywords: class switch; immunoglobulin class; mice; switch recombination ... See more keywords
53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.06.035
Abstract: Summary Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector functions of antibodies. CSR occurs via the formation and non-homologous end joining (NHEJ) repair of programmed DNA double-strand breaks (DSBs) at… read more here.
Keywords: end; dna double; class switch; switch recombination ... See more keywords
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
Sign Up to like & getrecommendations! Published in 2019 at "Immunity"
DOI: 10.1016/j.immuni.2019.07.001
Abstract: Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell… read more here.
Keywords: class switch; germinal centers; switch recombination; recombination ... See more keywords
RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.04.001
Abstract: Summary Class switch recombination (CSR) at the immunoglobulin heavy-chain (IgH) locus is associated with the formation of R-loop structures over switch (S) regions. While these often occur co-transcriptionally between nascent RNA and template DNA, we… read more here.
Keywords: helicase ddx1; rna helicase; switch; class switch ... See more keywords
The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.08.042
Abstract: Summary Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector component of antibody responses. CSR is initiated by activation-induced cytidine deaminase (AID), which targets transcriptionally active immunoglobulin heavy chain (Igh) switch… read more here.
Keywords: switch; chromatin reader; class switch; zmynd8 ... See more keywords
MicroRNA‐146a promotes IgE class switch in B cells via upregulating 14‐3‐3&sgr; expression
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.10.023
Abstract: HighlightsIgE antibody increases significantly in miR‐146a overexpression mice.IgE antibody level is higher in TG B cell cultures than in controls.MiR‐146a enhances IgE class switch and secretion in B cells by upregulating 14‐3‐3&sgr; expression.OVA‐specific IgE antibody… read more here.
Keywords: expression; antibody; mir 146a; class switch ... See more keywords
AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0008
Abstract: Immunoglobulin class switch recombination (CSR) plays critical roles in controlling infections and inflammatory tissue injuries. Here, we show that AFF3, a candidate gene for both rheumatoid arthritis and type 1 diabetes, is a molecular facilitator… read more here.
Keywords: switch recombination; switch; molecular facilitator; immunoglobulin class ... See more keywords
Immunoglobulin Class Switch Recombination Is Initiated by Rare Cytosine Deamination Events at Switch Regions
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00125-20
Abstract: Activation-induced cytidine deaminase (AID) initiates immunoglobulin (Ig) class switch recombination (CSR), somatic hypermutation (SHM), and gene conversion by converting DNA cytosines to uracils at specific genomic regions. In this study, we examined AID footprints across… read more here.
Keywords: switch region; class switch; aid; deamination ... See more keywords
Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01784
Abstract: A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are generated through genetic recombination and can be diversified through somatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of… read more here.
Keywords: health; cell; cell receptor; class switch ... See more keywords
Class-Switch Recombination (CSR)/Hyper-IgM (HIGM) Syndromes and Phosphoinositide 3-Kinase (PI3K) Defects
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02172
Abstract: Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination… read more here.
Keywords: higm syndromes; class switch; igm; switch recombination ... See more keywords
Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.870933
Abstract: Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin constant gene exons.… read more here.
Keywords: switch recombination; switch; recombination; end joining ... See more keywords