B cell class switching in intestinal immunity in health and disease
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13139
Abstract: The gastrointestinal tract is colonized by trillions of commensal microorganisms that collectively form the microbiome and make essential contributions to organism homeostasis. The intestinal immune system must tolerate these beneficial commensals, whilst preventing pathogenic organisms… read more here.
Keywords: intestinal immunity; class switching; disease; class ... See more keywords
Class switching is differentially regulated in RBC alloimmunization and vaccination
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DOI: 10.1111/trf.17301
Abstract: Studies of human patients have shown that most anti‐RBC alloantibodies are IgG1 or IgG3 subclasses, although it is unclear why transfused RBCs preferentially drive these subclasses over others. Though mouse models allow for the mechanistic… read more here.
Keywords: class switching; rbc alloimmunization; switching differentially; vaccination ... See more keywords
Tripterygium Wilfordii inhibits tonsillar IgA production by downregulating IgA class switching in IgA nephropathy
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DOI: 10.18632/oncotarget.22561
Abstract: IgA nephropathy (IgAN) is characterized by high serum IgA levels and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils, where present enhancement of IgA production… read more here.
Keywords: iga; class switching; iga production; iga class ... See more keywords
Multimericity Amplifies the Synergy of BCR and TLR4 for B Cell Activation and Antibody Class Switching
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DOI: 10.3389/fimmu.2022.882502
Abstract: Sustained signaling through the B cell antigen receptor (BCR) is thought to occur only when antigen(s) crosslink or disperse multiple BCR units, such as by multimeric antigens found on the surfaces of viruses or bacteria.… read more here.
Keywords: cell; class switching; class; cell activation ... See more keywords