Pembrolizumab Added to Ifosfamide, Carboplatin, and Etoposide Chemotherapy for Relapsed or Refractory Classic Hodgkin Lymphoma: A Multi-institutional Phase 2 Investigator-Initiated Nonrandomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.7975
Abstract: Importance To our knowledge, this is the first clinical trial designed to investigate concurrent treatment with a checkpoint inhibitor and conventional chemotherapy in relapsed or refractory classic Hodgkin lymphoma in patients destined for an autologous… read more here.
Keywords: hodgkin lymphoma; relapsed refractory; refractory classic; chemotherapy ... See more keywords
Long‐term risk of cardiovascular disease mortality among classic Hodgkin lymphoma survivors
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DOI: 10.1002/cncr.34375
Abstract: The temporal trend of cardiovascular disease (CVD) mortality in patients with classic Hodgkin lymphoma (cHL) throughout follow‐up remains unclear. This study aimed to assess this temporal trend in patients with cHL. read more here.
Keywords: cardiovascular disease; mortality; hodgkin lymphoma; classic hodgkin ... See more keywords
Flow cytometry assessment of reactive T‐cells distinguishes classic Hodgkin lymphoma from benign lymphadenopathy in children
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24661
Abstract: Detection of classic Hodgkin lymphoma (cHL) neoplastic cells using flow cytometric immunophenotyping (FCI) remains limited. We hypothesized that characterization of the reactive infiltrates could assist in diagnosing cHL in children. read more here.
Keywords: hodgkin lymphoma; flow cytometry; assessment reactive; classic hodgkin ... See more keywords
Molecular profiling of cell-free DNA from classic Hodgkin lymphoma patients identifies potential prognostic clusters and corresponds with disease dynamics
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-025-06328-8
Abstract: Cell-free DNA (cfDNA) analysis has advantages over tissue analysis for molecular profiling of classic Hodgkin lymphoma (cHL) at diagnosis and offers additional opportunities for sensitive non-invasive disease tracking during treatment. The aim of this study… read more here.
Keywords: disease; classic hodgkin; molecular profiling; free dna ... See more keywords
Lymph node transcriptomic profiles suggest susceptibility to bleomycin-induced pulmonary toxicity in classic hodgkin lymphoma
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DOI: 10.1038/s41598-025-16218-8
Abstract: Despite advances in reducing treatment-related toxicities, predictive biomarkers for bleomycin-induced pulmonary toxicity (BPT) remain undefined. Affecting around 10% of classic Hodgkin lymphoma (CHL) and associated with a mortality rate of 10–20%, BPT poses a clinical… read more here.
Keywords: classic hodgkin; induced pulmonary; toxicity; chl ... See more keywords
The value of thymus and activation related chemokine immunohistochemistry in classic Hodgkin lymphoma diagnostics
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14836
Abstract: Classic Hodgkin lymphoma (cHL) should be distinguished from its wide variety of histological mimics, including reactive conditions and mature B and T cell neoplasms. Thymus and activation‐related chemokine (TARC) is produced in extremely high quantities… read more here.
Keywords: hodgkin lymphoma; activation related; related chemokine; thymus activation ... See more keywords
Multiplexed Spatial Profiling of Hodgkin Reed–Sternberg Cell Neighborhoods in Classic Hodgkin Lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-24-0942
Abstract: Abstract Purpose: Classic Hodgkin lymphoma (cHL) is a B-cell lymphoma that occurs primarily in young adults and, less frequently, in elderly individuals. A hallmark of cHL is the exceptional scarcity (1%–5%) of the malignant Hodgkin… read more here.
Keywords: classic hodgkin; hrs cells; hodgkin; cell ... See more keywords
Dissecting Clonal Hematopoiesis in Tissues of Patients with Classic Hodgkin Lymphoma.
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DOI: 10.1158/2643-3230.bcd-20-0203
Abstract: Clonal hematopoiesis predisposes to hematologic malignancies. However, clonal hematopoiesis is understudied in classic Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in 40 cHL cases by sequencing… read more here.
Keywords: blood; hematopoiesis; hodgkin lymphoma; clonal hematopoiesis ... See more keywords
Classic Hodgkin Lymphoma With Primary Presentation as Lytic Bone Lesions and Pancytopenia: Report of a Pediatric Case and Review of Literature
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DOI: 10.1177/10935266251326216
Abstract: In this report, we describe a case of classic Hodgkin lymphoma presenting with lytic bone lesions and pancytopenia, but with no significant lymphadenopathy or mediastinal mass. We report detailed clinical, radiologic, and pathologic findings. We… read more here.
Keywords: report; classic hodgkin; hodgkin lymphoma; lytic bone ... See more keywords
Development of a High-Throughput Multiplex Immunofluorescence Pipeline in Classic Hodgkin Lymphoma Whole Slide Formalin-Fixed Paraffin-Embedded Tissue Samples
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DOI: 10.1182/blood-2024-211077
Abstract: Classic Hodgkin Lymphoma (cHL) is characterized by the presence of abnormal large cells known as Hodgkin Reed-Sternberg (HRS) cells. Curative intent chemotherapy has a 90% response rate, but for refractory patients, current immunotherapies remain insufficient.… read more here.
Keywords: classic hodgkin; chl; cell; multiplex immunofluorescence ... See more keywords
Tumor microenvironment differences between diagnostic and relapsed classic Hodgkin lymphoma revealed by scRNA-seq.
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DOI: 10.1182/bloodadvances.2025017107
Abstract: Key Points • Naïve B cells expressing LGALS9 (galectin-9) are distinctly increased in early-relapse CHL compared to diagnostic and late-relapse samples.• Galectin-9–positive naïve B cells engage with TIM-3+ T cells, potentially contributing to an immunosuppressive… read more here.
Keywords: microenvironment differences; classic hodgkin; tumor microenvironment; diagnostic relapsed ... See more keywords