A Randomized, First‐in‐Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1111
Abstract: Aberrant activation of the classical complement pathway is the common underlying pathophysiology of orphan diseases such as bullous pemphigoid, antibody‐mediated rejection of organ transplants, cold agglutinin disease, and warm autoimmune hemolytic anemia. Therapeutic options for… read more here.
Keywords: inhibition classical; sutimlimab humanized; complement pathway; classical complement ... See more keywords
Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.06.009
Abstract: Abstract Microglia‐mediated neuroinflammation is widely associated with seizures and epilepsy. Although microglial cells are professional phagocytes, less is known about the status of this phenotype in epilepsy. Recent evidence supports that phagocytosis‐associated molecules from the… read more here.
Keywords: epilepsy; classical complement; complement; phagocytosis signaling ... See more keywords
Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.10.008
Abstract: Complement protein C1q plays a dual role in a number of inflammatory diseases such as atherosclerosis. While in later stages classical complement pathway activation by C1q exacerbates disease progression, C1q also plays a beneficial role… read more here.
Keywords: rc1q; complement pathway; classical complement; c1q ... See more keywords
First‐in‐human study with SAR445088: A novel selective classical complement pathway inhibitor
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DOI: 10.1111/cts.13481
Abstract: SAR445088 is an anti‐C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system and has the potential to provide clinical benefit in the treatment of complement‐mediated diseases. A… read more here.
Keywords: complement; complement pathway; complement mediated; classical complement ... See more keywords
SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.838780
Abstract: Antibodies specific for the spike glycoprotein (S) and nucleocapsid (N) SARS-CoV-2 proteins are typically present during severe COVID-19, and induced to S after vaccination. The binding of viral antigens by antibody can initiate the classical… read more here.
Keywords: induced vaccination; classical complement; complement; complement activation ... See more keywords