The unconventional role of HLA-E: The road less traveled.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.02.011
Abstract: Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait… read more here.
Keywords: classical hla; hla; immune system; hla molecules ... See more keywords
A large-scale investigation into the role of classical HLA loci in multiple types of severe infections, with a focus on overlaps with autoimmune and mental disorders
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-02888-1
Abstract: Background Infections are a major disease burden worldwide. While they are caused by external pathogens, host genetics also plays a part in susceptibility to infections. Past studies have reported diverse associations between human leukocyte antigen… read more here.
Keywords: severe infections; hla alleles; etiology; classical hla ... See more keywords
Type 1 Diabetes and the HLA Region: Genetic Association Besides Classical HLA Class II Genes
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.683946
Abstract: Type 1 diabetes is an autoimmune disease with rising incidence in high-income countries. Genetic and environmental predisposing factors contribute to the etiology of the disease, although their interaction is not sufficiently understood to allow for… read more here.
Keywords: etiology; hla region; classical hla; association ... See more keywords
Immunomodulatory Potential of Non-Classical HLA-G in Infections including COVID-19 and Parasitic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020257
Abstract: Human Leukocyte Antigen-G (HLA-G), a polymorphic non-classical HLA (HLA-Ib) with immune-regulatory properties in cancers and infectious diseases, presents both membrane-bound and soluble (sHLA-G) isoforms. Polymorphism has implications in host responses to pathogen infections and in… read more here.
Keywords: hla; potential non; immunomodulatory potential; classical hla ... See more keywords
European Patent in Immunoncology: From Immunological Principles of Implantation to Cancer Treatment
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20081830
Abstract: The granted European patent EP 2 561 890 describes a procedure for an immunological treatment of cancer. It is based on the principles of the HLA-supported communication of implantation and pregnancy. These principles ensure that… read more here.
Keywords: hla; european patent; non classical; classical hla ... See more keywords
Non-Classical HLA Determinants of the Clinical Response after Autologous Stem Cell Transplantation for Systemic Sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137223
Abstract: Systemic Sclerosis (SSc) is a chronic autoimmune disease with high morbidity and mortality. Autologous Hematopoietic Stem Cell Transplantation (AHSCT) is the best therapeutic option for rapidly progressive SSc, allowing increased survival with regression of skin… read more here.
Keywords: clinical response; hla hla; hla; non classical ... See more keywords