Genotyping of Classical Hodgkin Lymphoma on the Liquid Biopsy
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DOI: 10.1002/hon.2437_51
Abstract: Non‐Hodgkin's lymphoma‐tailored small compound inhibitors of BCR signaling, ibrutinib and idelalisib, where dramatic death rates were observed after priming with two restore agents. Further investigations, including pre‐clinical mouse trials, are currently in progress and will… read more here.
Keywords: lymphoma liquid; classical hodgkin; hodgkin lymphoma; genotyping classical ... See more keywords
Epstein‐Barr virus positivity is associated with angiogenesis in, and poorer survival of, patients receiving standard treatment for classical Hodgkin's lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2468
Abstract: Epstein‐Barr virus (EBV) is a significant contributor to the development of classical Hodgkin's lymphoma (cHL). Recent studies have documented associations between angiogenesis and EBV‐associated malignancies. No study has yet examined the associations among, and prognostic… read more here.
Keywords: epstein barr; angiogenesis; hodgkin lymphoma; classical hodgkin ... See more keywords
RESPONSE‐ADAPTED TREATMENT WITH NIVOLUMAB AND BRENTUXIMAB VEDOTIN IN YOUNG PATIENTS WITH RELAPSED/REFRACTORY CLASSICAL HODGKIN LYMPHOMA: CHECKMATE 744 SUBGROUP ANALYSES
Sign Up to like & getrecommendations! Published in 2019 at "Hematological Oncology"
DOI: 10.1002/hon.26_2629
Abstract: Introduction: This study regimen is based on theGPOH-HD 2002 study that demonstrated 5-year EFS and OS of 87% and 95% respectively with 6 cycles OEPA/COPDAC and 20-30 Gy IFRT. The subsequent EuroNet-C1 study showed that… read more here.
Keywords: hodgkin lymphoma; response; classical hodgkin; study ... See more keywords
Classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder in a kidney transplant recipient: a diagnostic pitfall
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-018-2410-x
Abstract: We report a case of classical Hodgkin lymphoma type post-transplant lymphoproliferative disorder (HL-PTLD) after kidney transplantation to highlight the difficulty of distinguishing this disorder from Hodgkin lymphoma-like PTLD (HL-like PTLD). Through this case report and… read more here.
Keywords: lymphoma; lymphoproliferative disorder; hodgkin lymphoma; classical hodgkin ... See more keywords
MicroRNA signature in classical Hodgkin lymphoma
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DOI: 10.1007/s13353-021-00614-7
Abstract: Classical Hodgkin lymphoma (cHL) is one of the most prevalent lymphomas with a unique cell composition compared to other lymphoma entities. Rare, malignant Hodgkin and Reed-Sternberg (HRS) cells embedded with an extensive but ineffective immune… read more here.
Keywords: lymphoma; hodgkin lymphoma; classical hodgkin; mir mir ... See more keywords
Promising remissions in relapsed refractory classical Hodgkin lymphoma patients requiring multiple salvage regimens before transplantation in the brentuximab vedotin era
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DOI: 10.1016/j.lrr.2021.100276
Abstract: Relapsed/refractory classical Hodgkin lymphoma (R/R cHL) patients refractory to first line salvage have poor outcomes. Herein we report the outcome of R/R cHL patients requiring ≥two vs. one line in the era of chemo-immunotherapy. Among… read more here.
Keywords: relapsed refractory; patients requiring; hodgkin lymphoma; classical hodgkin ... See more keywords
Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma
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DOI: 10.1038/leu.2016.238
Abstract: Apart from its unique histopathological appearance with rare tumor cells embedded in an inflammatory background of bystander cells, classical Hodgkin lymphoma (cHL) is characterized by an unusual activation of a broad range of signaling pathways… read more here.
Keywords: lymphoma; classical hodgkin; pdlim2; inactivation ... See more keywords
PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
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DOI: 10.1038/s41375-020-0737-9
Abstract: In classical Hodgkin lymphoma (cHL)—characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells—tumor-associated macrophages (TAMs) play a pivotal role in tumor formation. However, the significance of direct contact between HRS cells and TAMs has… read more here.
Keywords: trogocytosis; classical hodgkin; hrs; hrs cells ... See more keywords
An evaluation of pembrolizumab for classical Hodgkin lymphoma
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DOI: 10.1080/17474086.2022.2061947
Abstract: ABSTRACT Introduction Pembrolizumab is an immune checkpoint inhibitor (ICI) targeted against the programmed death 1 (PD-1) pathway, a key pathway in the biology of Classical Hodgkin lymphoma (cHL). Anti-PD-1 antibodies are approved for use in… read more here.
Keywords: hodgkin lymphoma; pembrolizumab; biology; classical hodgkin ... See more keywords
CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2033433
Abstract: ABSTRACT In classical Hodgkin lymphoma (cHL), the highly abundant CD4+ T cells in the vicinity of tumor cells are considered essential for tumor cell survival, but are ill-defined. Although they are activated, they consistently lack… read more here.
Keywords: cell; cd26; classical hodgkin; cd4 ... See more keywords
Classical Hodgkin lymphoma producing macrophage colony‐stimulating factor with resultant monocytosis
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14416
Abstract: A 71-year-old Japanese woman presented with a fever of 38°C and weight loss. The results of her blood analysis were as follows: white blood cell count 4 8 9 10/l (58% neutrophils, 21% lymphocytes, 20%… read more here.
Keywords: classical hodgkin; stimulating factor; macrophage colony; colony stimulating ... See more keywords