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Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2068445
Abstract: Abstract Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it remains to…
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Keywords:
complement activation;
anca associated;
activation classical;
pathway ... See more keywords
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Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01504
Abstract: The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro characterization…
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Keywords:
classical pathway;
inhibitor;
pathway complement;
c1q ... See more keywords
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Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.715704
Abstract: The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the AP C3 convertase named C3…
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Keywords:
classical pathway;
immune complex;
c3g;
convertase ... See more keywords