Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2068445
Abstract: Abstract Background Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is the fulminant glomerular diseases with poor renal prognosis. Activation of the complement system has recently been reported in the pathogenesis of AAGN, but it remains to… read more here.
Keywords: complement activation; anca associated; activation classical; pathway ... See more keywords
Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System
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DOI: 10.3389/fimmu.2020.01504
Abstract: The classical pathway of complement is important for protection against pathogens and in maintaining tissue homeostasis, but excessive or aberrant activation is directly linked to numerous pathologies. We describe the development and in vitro characterization… read more here.
Keywords: classical pathway; inhibitor; pathway complement; c1q ... See more keywords
Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis
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DOI: 10.3389/fimmu.2021.715704
Abstract: The rare and heterogeneous kidney disorder C3 glomerulopathy (C3G) is characterized by dysregulation of the alternative pathway (AP) of the complement system. C3G is often associated with autoantibodies stabilizing the AP C3 convertase named C3… read more here.
Keywords: classical pathway; immune complex; c3g; convertase ... See more keywords