Mutations in Classical Signaling Pathways and Their Functional Impact in Microsatellite Instability High Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2022.0118
Abstract: Aims: Colorectal carcinomas with microsatellite instability high (MSI-H) are a distinctive group among colorectal cancers (CRCs). This study investigated the mutations of genes in the common signaling pathways and their potential clinical implications in MSI-H… read more here.
Keywords: microsatellite instability; classical signaling; instability high; mutations classical ... See more keywords
IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019000396
Abstract: Graft-versus-host-disease (GVHD) after allogeneic stem cell transplantation (alloSCT) is characterized by interleukin 6 (IL-6) dysregulation. IL-6 can mediate effects via various pathways, including classical, trans and cluster signaling. Given the recent availability of agents that… read more here.
Keywords: classical signaling; versus host; dysregulation; host disease ... See more keywords
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells
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DOI: 10.1371/journal.pone.0203395
Abstract: IL-6 is required for the response of mice against Listeria monocytogenes. Control of infection depends on classical IL-6 signaling via membrane IL-6Rα, but IL-6 target cells and protective mechanisms remain unclear. We used mice with… read more here.
Keywords: myeloid cells; control; classical signaling; control listeria ... See more keywords