Comparative Genomic Analysis Reveals Key Changes in the Genome of Acremonium chrysogenum That Occurred During Classical Strain Improvement for Production of Antibiotic Cephalosporin C
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DOI: 10.3390/ijms26010181
Abstract: From the 1950s to the present, the main tool for obtaining fungal industrial producers of secondary metabolites remains the so-called classical strain improvement (CSI) methods associated with multi-round random mutagenesis and screening for the level… read more here.
Keywords: classical strain; chrysogenum; cephalosporin; strain improvement ... See more keywords