Classics in Chemical Neuroscience: Baclofen.
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DOI: 10.1021/acschemneuro.0c00254
Abstract: Baclofen, -(4-chlorophenyl)--aminobutyric acid, holds a unique position in neuroscience, remaining the only FDA approved GABAB agonist. While intended to be a more brain penetrant version of GABA (-aminobutyric acid) for the potential treatment of epilepsy,… read more here.
Keywords: neuroscience baclofen; treatment; chemical neuroscience; classics chemical ... See more keywords
DARK Classics in Chemical Neuroscience: Salvinorin A.
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DOI: 10.1021/acschemneuro.0c00608
Abstract: Salvinorin A is the main bioactive compound in Salvia divinorum, an endemic plant with ancestral use by the inhabitants of the Mazateca mountain range (Sierra Mazateca) in Oaxaca, México. The main use of la pastora,… read more here.
Keywords: salvinorin; dark classics; chemical neuroscience; chemistry ... See more keywords
DARK Classics in Chemical Neuroscience: Methaqualone.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00697
Abstract: Commonly known as "Quaaludes," methaqualone (1) is a sedative-hypnotic medication, with effects resembling barbiturates and other downers, that exerts its effects through modulation of γ-aminobutyric acid type A receptors (GABAAR). Following the discovery of the… read more here.
Keywords: chemical neuroscience; dark classics; methaqualone; classics chemical ... See more keywords
DARK Classics in Chemical Neuroscience: Morphine.
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DOI: 10.1021/acschemneuro.8b00150
Abstract: As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chemists seeking… read more here.
Keywords: dark classics; morphine; chemical neuroscience; classics chemical ... See more keywords
Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine.
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DOI: 10.1021/acschemneuro.8b00155
Abstract: Better known as "ecstasy", 3,4-methylenedioxymethamphetamine (MDMA) is a small molecule that has played a prominent role in defining the ethos of today's teenagers and young adults, much like lysergic acid diethylamide (LSD) did in the… read more here.
Keywords: dark classics; methylenedioxymethamphetamine; chemical neuroscience; classics chemical ... See more keywords
DARK Classics in Chemical Neuroscience: Psilocybin.
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DOI: 10.1021/acschemneuro.8b00186
Abstract: Psilocybin is found in a family of mushrooms commonly known as "magic mushrooms" that have been used throughout history to induce hallucinations. In the late 1950s Albert Hofmann, of Sandoz Laboratories, identified and synthesized the… read more here.
Keywords: dark classics; chemical neuroscience; classics chemical; psilocybin ... See more keywords
DARK Classics in Chemical Neuroscience: Opium, a Friend or Foe.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00546
Abstract: Opium has found great use medicinally for its analgesic properties and has been witnessed as one of the most popular medications used in psychiatry. Opium derivatives have been shown as efficacious for relieving pain and… read more here.
Keywords: dark classics; chemical neuroscience; opium derivatives; opium ... See more keywords
DARK Classics in Chemical Neuroscience: Arecoline.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00711
Abstract: Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm ( Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes… read more here.
Keywords: dark classics; arecoline; neuroscience arecoline; chemical neuroscience ... See more keywords