Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations
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DOI: 10.1038/s41388-018-0171-x
Abstract: The RAS–RAF–MEK–ERK signaling cascade is among the most frequently mutated pathways in human cancer. Approximately 50% of melanoma patients possess a druggable hotspot V600E/K mutation in the BRAF protein kinase. FDA-approved combination therapies of BRAF… read more here.
Keywords: braf alterations; braf; cancer; non v600 ... See more keywords