Parkinson disease and clathrin coat dynamics at synapses, why not?
Sign Up to like & getrecommendations! Published in 2017 at "Movement Disorders"
DOI: 10.1002/mds.27097
Abstract: In 2013, the missense p.Arg258Gln (R258Q) mutation in the Suppressor of actin (SAC domain) of Synaptojanin 1 (SYNJ1) was linked to a recessive form of early onset of Parkinson’s disease (PD) in 3 independent families.… read more here.
Keywords: clathrin coat; accumulation; disease; parkinson disease ... See more keywords
Construction and Functionalization of a Clathrin Assembly for a Targeted Protein Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204620
Abstract: Protein assemblies have drawn much attention as platforms for biomedical applications, including gene/drug delivery and vaccine, due to biocompatibility and functional diversity. Here, the construction and functionalization of a protein assembly composed of human clathrin… read more here.
Keywords: construction functionalization; targeted protein; clathrin assembly; clathrin ... See more keywords
Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Cell"
DOI: 10.1016/j.devcel.2019.07.017
Abstract: Summary Clathrin-mediated endocytosis (CME) is key to maintaining the transmembrane protein composition of cells’ limiting membranes. During mammalian CME, a reversible phosphorylation event occurs on Thr156 of the μ2 subunit of the main endocytic clathrin… read more here.
Keywords: phosphorylation; endocytic clathrin; formation; clathrin coated ... See more keywords
Mechanisms of Carrier Formation during Clathrin-Independent Endocytosis.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.11.004
Abstract: Clathrin-independent endocytosis (CIE) mediates the cellular uptake of many extracellular ligands, receptors, and pathogens, including several life-threatening bacterial toxins and viruses. So far, our understanding of CIE carrier formation has lagged behind that of clathrin-coated… read more here.
Keywords: cie; carrier formation; independent endocytosis; endocytosis ... See more keywords
DeepCLA: A Hybrid Deep Learning Approach for the Identification of Clathrin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c00979
Abstract: Clathrin is a highly evolutionarily conserved protein, which can affect membrane cleavage and membrane release of vesicles. The absence of clathrin in the cellular system affects a variety of human diseases. Effective recognition of clathrin… read more here.
Keywords: network; deep learning; deepcla; approach ... See more keywords
Self-Assembly of Mesoscale Artificial Clathrin Mimics.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.7b03739
Abstract: Fluidic control and sampling in complex environments is an important process in biotechnology, materials synthesis, and microfluidics. An elegant solution to this problem has evolved in nature through cellular endocytosis, where the dynamic recruitment, self-assembly,… read more here.
Keywords: clathrin mimics; self assembly; assembly mesoscale; artificial clathrin ... See more keywords
Modifying Membrane Morphology and Interactions with DNA Origami Clathrin-Mimic Networks
Sign Up to like & getrecommendations! Published in 2019 at "ACS Nano"
DOI: 10.1021/acsnano.8b07734
Abstract: We describe the triggered assembly of a bioinspired DNA origami meshwork on a lipid membrane. DNA triskelia, three-armed DNA origami nanostructures inspired by the membrane-modifying protein clathrin, are bound to lipid mono- and bilayers using… read more here.
Keywords: membrane morphology; dna origami; membrane; clathrin ... See more keywords
A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating
Sign Up to like & getrecommendations! Published in 2018 at "Cell Discovery"
DOI: 10.1038/s41421-018-0067-5
Abstract: Kif5b-driven anterograde transport and clathrin-mediated endocytosis (CME) are responsible for opposite intracellular trafficking, contributing to plasma membrane homeostasis. However, whether and how the two trafficking processes coordinate remain unclear. Here, we show that Kif5b directly… read more here.
Keywords: new role; large clathrin; clathrin coated; mediated endocytosis ... See more keywords
Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03533-0
Abstract: Although essential for many cellular processes, the sequence of structural and molecular events during clathrin-mediated endocytosis remains elusive. While it was long believed that clathrin-coated pits grow with a constant curvature, it was recently suggested… read more here.
Keywords: clathrin coat; transition; microscopy; coat endocytosis ... See more keywords
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05345-8
Abstract: The endosomal sorting complex required for transport (ESCRT) machinery mediates cargo sorting, membrane deformation and membrane scission on the surface of endosomes, generating intraluminal vesicles (ILVs) to degrade signaling receptors. By live-cell imaging of individual… read more here.
Keywords: vesicle; recruitment; formation; ilv formation ... See more keywords
Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09259-w
Abstract: Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds (e.g. auxilin) to millions (e.g. clathrin). These variations contain important information about… read more here.
Keywords: clathrin mediated; clathrin; copy numbers; network ... See more keywords