Basolateral Sorting of the Sodium/Iodide Symporter Is Mediated by Adaptor Protein 1 Clathrin Adaptor Complexes
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DOI: 10.1089/thy.2022.0163
Abstract: Background: The sodium/iodide symporter (NIS) is a transmembrane protein located on the basolateral membrane of thyrocytes. Despite its physiological and clinical relevance, little is known about the mechanisms that mediate NIS subcellular sorting. In the… read more here.
Keywords: clathrin adaptor; adaptor complexes; nis; adaptor ... See more keywords
Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes
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DOI: 10.1091/mbc.e18-12-0811
Abstract: Megalin (gp330, LRP-2) is a protein structurally related to the low-density lipoprotein receptor family that displays a large luminal domain with multiligand binding properties. Megalin localizes to the apical surface of multiple epithelia, where it… read more here.
Keywords: clathrin clathrin; megalin biosynthetic; trafficking; megalin ... See more keywords
Prd1 associates with the clathrin adaptor α-Adaptin and the kinesin-3 Imac/Unc-104 to govern dendrite pruning in Drosophila
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DOI: 10.1371/journal.pbio.2004506
Abstract: Refinement of the nervous system depends on selective removal of excessive axons/dendrites, a process known as pruning. Drosophila ddaC sensory neurons prune their larval dendrites via endo-lysosomal degradation of the L1-type cell adhesion molecule (L1-CAM),… read more here.
Keywords: unc 104; prd1; dendrite pruning; pruning drosophila ... See more keywords
Dual role of the Toxoplasma gondii clathrin adaptor AP1 in the sorting of rhoptry and microneme proteins and in parasite division
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DOI: 10.1371/journal.ppat.1006331
Abstract: Toxoplasma gondii possesses a highly polarized secretory system, which efficiently assembles de novo micronemes and rhoptries during parasite replication. These apical secretory organelles release their contents into host cells promoting parasite invasion and survival. Using… read more here.
Keywords: parasite division; microneme proteins; gondii; toxoplasma gondii ... See more keywords