Inhibition Clathrin Mediated Endocytosis: Pitstop 1 and Pitstop 2 Chimeras
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400253
Abstract: Twenty‐five chimera compounds of Pitstop 1 and 2 were synthesised and screened for their ability to block the clathrin terminal domain‐amphiphysin protein‐protein interaction (NTD‐PPI using an ELISA) and clathrin mediated endocytosis (CME) in cells. Library… read more here.
Keywords: pitstop; clathrin mediated; ppi inhibition; mediated endocytosis ... See more keywords
Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113675
Abstract: Cellular stimuli that increase diacylglycerol levels activate several protein kinase C (PKC) isoforms; however, prolonged stimulation depletes cells of PKCs. Ubiquitination is a critical cellular event that mediates the degradation of numerous proteins, including PKCs,… read more here.
Keywords: nucleus; clathrin mediated; mdm2; ubiquitination pkc ... See more keywords
Involvement of adaptor proteins in clathrin-mediated endocytosis of virus entry.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105278
Abstract: The first step in the initiation of effective viral infection is breaking through the cytomembrane to enter the cell. Clathrin-mediated endocytosis is a key vesicular trafficking process in which a variety of cargo molecules are… read more here.
Keywords: clathrin mediated; mediated endocytosis; adaptor proteins; involvement adaptor ... See more keywords
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104948
Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each… read more here.
Keywords: clathrin mediated; kinase lrrk2; disease; parkinson disease ... See more keywords
Fullerol Initiates Stem Cell-Nanomaterials Interactions for Enhanced Tissue Regeneration via Clathrin-Mediated Endocytosis and Nuclear Factor Erythroid 2-Related Factor 2 Signaling.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c01731
Abstract: The advancement of nanomedicine requires a thorough understanding of the intrinsic bioactivity and molecular interactions of nanomaterials for safe and effective clinical applications, which remains lacking for most currently developed nanomaterials. Here, we uncover the… read more here.
Keywords: clathrin mediated; via clathrin; tissue regeneration; factor ... See more keywords
Mechanisms of clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.132
Abstract: Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis was first described over 5 decades ago. Since its… read more here.
Keywords: clathrin mediated; mediated endocytosis; biology; mechanisms clathrin ... See more keywords
GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02317-y
Abstract: Small GTPases play a critical role as regulatory molecules in signaling transduction and various cellular processes, contributing to the development of human diseases, including cancers. GPN3, an evolutionarily conserved member of the GPN-loop GTPase subfamily… read more here.
Keywords: egfr; clathrin mediated; gpn3; endocytosis ... See more keywords
Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63238-z
Abstract: Clathrin-mediated endocytosis internalizes proteins and lipids from the cell surface. A flexible condensate of initiator proteins catalyzes assembly of clathrin-coated vesicles in diverse organisms. Here we reveal that an endocytic adaptor protein, Epsin1, conditionally stabilizes… read more here.
Keywords: clathrin mediated; cargo; mediated endocytosis; condensation ... See more keywords
Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09259-w
Abstract: Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds (e.g. auxilin) to millions (e.g. clathrin). These variations contain important information about… read more here.
Keywords: clathrin mediated; clathrin; copy numbers; network ... See more keywords
The influence of nanoparticle shape on clathrin-mediated endocytosis by computational study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Materials Chemistry B"
DOI: 10.1039/d3tb00322a
Abstract: Nanoparticles have been widely used in biomedical applications, such as gene/drug. Among physicochemical properties, shape is a vital design parameter for tuning cell uptake of nanoparticles. However, the regulatory mechanism... read more here.
Keywords: nanoparticle shape; endocytosis computational; clathrin mediated; shape clathrin ... See more keywords
Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-12-0871
Abstract: Clathrin-mediated endocytosis controls internalization of many receptors from the cell surface. It was found that clathrin-mediated endocytosis of epidermal growth factor receptor (EGFR) but not that of transferrin receptor requires EGFR-activated phospholipase Cγ1, Ca2+ signals,… read more here.
Keywords: clathrin mediated; factor receptor; growth factor; endocytosis ... See more keywords