Mdm2-mediated ubiquitination of PKCβII in the nucleus mediates clathrin-mediated endocytic activity.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113675
Abstract: Cellular stimuli that increase diacylglycerol levels activate several protein kinase C (PKC) isoforms; however, prolonged stimulation depletes cells of PKCs. Ubiquitination is a critical cellular event that mediates the degradation of numerous proteins, including PKCs,… read more here.
Keywords: nucleus; clathrin mediated; mdm2; ubiquitination pkc ... See more keywords
Involvement of adaptor proteins in clathrin-mediated endocytosis of virus entry.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105278
Abstract: The first step in the initiation of effective viral infection is breaking through the cytomembrane to enter the cell. Clathrin-mediated endocytosis is a key vesicular trafficking process in which a variety of cargo molecules are… read more here.
Keywords: clathrin mediated; mediated endocytosis; adaptor proteins; involvement adaptor ... See more keywords
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104948
Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each… read more here.
Keywords: clathrin mediated; kinase lrrk2; disease; parkinson disease ... See more keywords
Mechanisms of clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.132
Abstract: Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis was first described over 5 decades ago. Since its… read more here.
Keywords: clathrin mediated; mediated endocytosis; biology; mechanisms clathrin ... See more keywords
Integrating protein copy numbers with interaction networks to quantify stoichiometry in clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-09259-w
Abstract: Proteins that drive processes like clathrin-mediated endocytosis (CME) are expressed at copy numbers within a cell and across cell types varying from hundreds (e.g. auxilin) to millions (e.g. clathrin). These variations contain important information about… read more here.
Keywords: clathrin mediated; clathrin; copy numbers; network ... See more keywords
The influence of nanoparticle shape on clathrin-mediated endocytosis by computational study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Materials Chemistry B"
DOI: 10.1039/d3tb00322a
Abstract: Nanoparticles have been widely used in biomedical applications, such as gene/drug. Among physicochemical properties, shape is a vital design parameter for tuning cell uptake of nanoparticles. However, the regulatory mechanism... read more here.
Keywords: nanoparticle shape; endocytosis computational; clathrin mediated; shape clathrin ... See more keywords
Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-12-0871
Abstract: Clathrin-mediated endocytosis controls internalization of many receptors from the cell surface. It was found that clathrin-mediated endocytosis of epidermal growth factor receptor (EGFR) but not that of transferrin receptor requires EGFR-activated phospholipase Cγ1, Ca2+ signals,… read more here.
Keywords: clathrin mediated; factor receptor; growth factor; endocytosis ... See more keywords
Early and nonredundant functions of dynamin isoforms in clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-06-0363
Abstract: Dynamin GTPases (Dyn1 and Dyn2) are indispensable proteins of the core clathrin-mediated endocytosis (CME) machinery. Best known for their role in fission at the late stages of CME, many studies have suggested that dynamin also… read more here.
Keywords: mediated endocytosis; clathrin mediated; stages cme; dynamin isoforms ... See more keywords
Membrane remodeling in clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.216812
Abstract: ABSTRACT Clathrin-mediated endocytosis is an essential cellular mechanism by which all eukaryotic cells regulate their plasma membrane composition to control processes ranging from cell signaling to adhesion, migration and morphogenesis. The formation of endocytic vesicles… read more here.
Keywords: protein; clathrin mediated; mediated endocytosis; membrane ... See more keywords
A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2000931
Abstract: Clathrin-mediated endocytosis (CME) and activity-dependent bulk endocytosis (ADBE) are two predominant forms of synaptic vesicle (SV) endocytosis, elicited by moderate and strong stimuli, respectively. They are tightly coupled with exocytosis for sustained neurotransmission. However, the… read more here.
Keywords: dependent bulk; clathrin mediated; bulk endocytosis; endocytosis ... See more keywords
Morphological changes of plasma membrane and protein assembly during clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Biology"
DOI: 10.1371/journal.pbio.2004786
Abstract: Clathrin-mediated endocytosis (CME) proceeds through a series of morphological changes of the plasma membrane induced by a number of protein components. Although the spatiotemporal assembly of these proteins has been elucidated by fluorescence-based techniques, the… read more here.
Keywords: morphological changes; clathrin mediated; changes plasma; mediated endocytosis ... See more keywords