Synthesis, 18F-labelling and radiopharmacological characterisation of the C-terminal 30mer of Clostridium perfringens enterotoxin as a potential claudin-targeting peptide
Sign Up to like & getrecommendations! Published in 2018 at "Amino Acids"
DOI: 10.1007/s00726-018-2657-9
Abstract: The cell surface receptor claudin-4 (Cld-4) is upregulated in various tumours and represents an important emerging target for both diagnosis and treatment of solid tumours of epithelial origin. The C-terminal fragment of the Clostridium perfringens… read more here.
Keywords: peptide; cld; claudin; clostridium perfringens ... See more keywords
Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1207-5
Abstract: It is important to understand the molecular mechanisms of barrier disruption in the central nervous system (CNS) of patients with multiple sclerosis (MS). The purpose of the present study was to clarify whether claudin-11 is… read more here.
Keywords: claudin; brain spinal; multiple sclerosis; brain ... See more keywords
Maintenance of claudin-3 expression and the barrier functions of intercellular junctions in parotid acinar cells via the inhibition of Src signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2017.05.007
Abstract: OBJECTIVES Salivary acinar and duct cells show different expression patterns of claudins, which may reflect their different functions. To study the role of claudins in saliva secretion, we examined alterations in the expression patterns of… read more here.
Keywords: claudin; parotid acinar; barrier function; expression ... See more keywords
Claudin-4 Shows Superior Specificity for Mesothelioma vs Non-Small Cell Lung Carcinoma Compared to MOC-31 and Ber-EP4.
Sign Up to like & getrecommendations! Published in 2020 at "Human pathology"
DOI: 10.1016/j.humpath.2020.04.005
Abstract: The distinction of malignant mesothelioma from non-small cell lung carcinoma (NSCLC) usually requires immunohistochemistry, but some broad spectrum carcinoma markers stain mesotheliomas and it remains unclear which broad spectrum markers are most valuable for separating… read more here.
Keywords: carcinoma; claudin; mesothelioma; ber ep4 ... See more keywords
Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies1
Sign Up to like & getrecommendations! Published in 2019 at "Translational Oncology"
DOI: 10.1016/j.tranon.2018.12.011
Abstract: Recent studies provide compelling evidence to suggest that the tight junction protein claudin 1, aberrantly expressed in several cancer types, plays an important role in cancer progression. Dysregulation of claudin 1 has been shown to… read more here.
Keywords: pkc; human breast; claudin; breast cancer ... See more keywords
Analysis of differential expression of tight junction proteins in cultured oral epithelial cells altered by Porphyromonas gingivalis, Porphyromonas gingivalis lipopolysaccharide, and extracellular adenosine triphosphate
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oral Science"
DOI: 10.1038/ijos.2017.51
Abstract: Tight junctions (TJs) are the most apical intercellular junctions of epithelial cells formed by occludin, claudins, junctional adhesion molecules (JAMs), and zonula occludens (ZO). Tight junction proteins can sense the presence of bacteria and regulate… read more here.
Keywords: claudin; porphyromonas gingivalis; gingivalis; junction proteins ... See more keywords
Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.156
Abstract: Schizophrenia is a neurodevelopmental disorder that affects up to 1% of the general population. Various genes show associations with schizophrenia and a very weak nominal association with the tight junction protein, claudin-5, has previously been… read more here.
Keywords: schizophrenia; modifying factor; claudin; expression claudin ... See more keywords
Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00304-1
Abstract: Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we… read more here.
Keywords: regulatory network; claudin; coding rnas; non coding ... See more keywords
Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay
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DOI: 10.1038/s41598-017-15108-y
Abstract: Claudins are key functional and structural components of tight junctions (TJs) in epithelial cell sheets. The C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds to claudin-4 and reversibly modulates intestinal TJ seals, thereby enhancing paracellular… read more here.
Keywords: binder attenuates; claudin; claudin binder; identification claudin ... See more keywords
Claudin-3-deficient C57BL/6J mice display intact brain barriers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-36731-3
Abstract: The tight junction protein claudin-3 has been identified as a transcriptional target of the Wnt/β-catenin signaling pathway regulating blood-brain barrier (BBB) maturation. In neurological disorders loss of claudin-3 immunostaining is observed at the compromised BBB… read more here.
Keywords: brain barriers; brain; claudin; c57bl mice ... See more keywords
Multiple claudin–claudin cis interfaces are required for tight junction strand formation and inherent flexibility
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0051-5
Abstract: Tight junctions consist of a network of sealing strands that create selective ion permeability barriers between adjoining epithelial or endothelial cells. The current model for tight junction strands consists of paired rows of claudins (Cldn)… read more here.
Keywords: cis; claudin; flexibility; formation ... See more keywords