Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13577
Abstract: Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on intestinal epithelial cells remains unclear.… read more here.
Keywords: expression; claudin expression; adrenomedullin alleviates; colitis ... See more keywords
Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2021.105012
Abstract: Classical swine fever (CSF) is one of the most epidemic viral diseases in swine industry. The causative pathogen is CSF virus (CSFV), a small enveloped RNA virus of Flaviviridae family. Claudin-1 was reported to be… read more here.
Keywords: csfv infection; infection; claudin expression; virus ... See more keywords
Serum amyloid A-induced blood-brain barrier dysfunction associated with decreased claudin-5 expression in rat brain endothelial cells and its inhibition by high-density lipoprotein in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135352
Abstract: The blood-brain barrier (BBB) is the multicellular interface located between the peripheral circulation and the brain parenchyma. BBB dysfunction is reported in many CNS diseases, such cognitive impairment, depression, Alzheimer's disease (AD), and multiple sclerosis… read more here.
Keywords: bbb; saa; dysfunction; claudin expression ... See more keywords
Claudin‐1 expression decreases with increasing pathological grade in actinic keratosis and may be a marker of high‐risk actinic keratosis
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13810
Abstract: Actinic keratosis (AK) is a common sun‐induced skin disorder that can progress to invasive squamous cell carcinoma. However, there is still no reliable method to predict high‐risk AK. read more here.
Keywords: high risk; expression decreases; claudin expression; keratosis ... See more keywords
Differential Expression of Claudin 1 and 4 in Basal Cell Carcinoma of the Skin
Sign Up to like & getrecommendations! Published in 2023 at "Dermatology Research and Practice"
DOI: 10.1155/2023/9936551
Abstract: Basal cell carcinoma (BCC) is the most common human malignancy. The biological behavior of this entity is remarkably indolent. Claudin plays an important role in tight junctions, regulating paracellular passage of variable substance including growth… read more here.
Keywords: grade; bcc; expression; basal cell ... See more keywords
Ling Zhi-8, a fungal immunomodulatory protein in Ganoderma lucidum, alleviates CPT-11-induced intestinal injury via restoring claudin-1 expression.
Sign Up to like & getrecommendations! Published in 2023 at "Aging"
DOI: 10.18632/aging.204695
Abstract: CPT-11 (Irinotecan) remains an important chemotherapeutic agent against various solid tumors nowadays. Potential adverse effects, especially gastrointestinal toxicities, are the main limiting factor for its clinical utility. Ling Zhi-8 (LZ-8), a fungal immunomodulatory protein in… read more here.
Keywords: induced intestinal; cpt induced; expression; claudin expression ... See more keywords
HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21190
Abstract: In normal colon, claudin-2 expression is restricted to the crypt bottom containing the undifferentiated and proliferative colonocytes. Claudin-2 expression is also upregulated in colorectal cancer (CRC) and promotes carcinogenesis. However, cellular mechanism/s regulated by increased… read more here.
Keywords: egfr erk1; claudin expression; expression; differentiation ... See more keywords
Claudin-1 Mediated Tight Junction Dysfunction as a Contributor to Atopic March
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.927465
Abstract: Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy tends to increase after atopic dermatitis. The mechanism underlying the progression of allergic inflammation from the skin to gastrointestinal (GI) tract… read more here.
Keywords: expression level; atopic march; claudin; claudin expression ... See more keywords
Claudins: Beyond Tight Junctions in Human IBD and Murine Models
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.682614
Abstract: Claudins are transmembrane proteins constituting one of three tight junction protein families. In patients with inflammatory bowel disease (IBD), disease activity–dependent changes in expression of certain claudins have been noted, thus making certain claudin family… read more here.
Keywords: expression; claudin claudin; animal models; claudin ... See more keywords
Temporal Effects of Quercetin on Tight Junction Barrier Properties and Claudin Expression and Localization in MDCK II Cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194889
Abstract: Kidney stones affect 10% of the population. Yet, there is relatively little known about how they form or how to prevent and treat them. The claudin family of tight junction proteins has been linked to… read more here.
Keywords: expression localization; tight junction; claudin expression;