MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
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DOI: 10.1038/s41416-019-0711-3
Abstract: Background Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs), particularly those that have high expression of MYC. However, the underlying… read more here.
Keywords: claudin low; fatty acid; myc; multigenic program ... See more keywords
Abstract B47: Silver nanoparticles exhibit subtype specific cytotoxic and therapeutic effects in claudin low breast cancer in vitro and in vivo
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DOI: 10.1158/1538-7445.epso16-b47
Abstract: Triple negative breast cancers (TNBC) are characterized by loss of expression of hormone receptors and decreased expression of the human epidermal growth factor receptor 2 (HER2). TNBC patients do not benefit from current targeted breast… read more here.
Keywords: low breast; breast; clbc; breast cancer ... See more keywords
Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94296
Abstract: The complex signaling networks of the tumor microenvironment that facilitate tumor growth and progression toward metastatic disease are becoming a focus of potential therapeutic options. The chemokine IL-8 is overexpressed in multiple cancer types, including… read more here.
Keywords: breast cancer; cancer; claudin low; mesenchymalization ... See more keywords
Re-expression of miR-200s in claudin‐low mammary tumor cells alters cell shape and reduces proliferation and invasion potentially through modulating other miRNAs and SUZ12 regulated genes
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DOI: 10.1186/s12935-021-01784-4
Abstract: Background MicroRNAs are a class of non-coding RNAs that regulate gene expression through binding to mRNAs and preventing their translation. One family of microRNAs known as the miR-200 family is an important regulator of epithelial… read more here.
Keywords: mir 200s; tumor cells; expression; mammary tumor ... See more keywords
Re-expression of miR-200c suppresses proliferation, colony formation and in vivo tumor growth of murine claudin-low mammary tumor cells
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DOI: 10.18632/oncotarget.15829
Abstract: Claudin-low breast cancer is a relatively rare breast cancer subtype. These cancers are typically ER−/PR−/HER2− and express high levels of mesenchymal genes as well as genes associated with inflammation, angiogenesis and stem cell function. In… read more here.
Keywords: claudin low; mir 200; mir 200c; growth ... See more keywords
Metastasis inhibition by BRMS1 and miR-31 replacement therapy in claudin-low cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2019.35674.8500
Abstract: Objective(s): The growing trend of research demonstrates that dynamic expression of two metastasis repressor classes (metastasis suppressor genes and anti-metastatic miRNA) has a close relationship with tumor invasion and metastasis. Using different strategies, it was… read more here.
Keywords: claudin low; metastasis; brms1; cell ... See more keywords
Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1020729
Abstract: Background In bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) and immunological feature. Although we have previously identified individual claudin members as prognostic biomarkers in clear cell… read more here.
Keywords: cell; cell carcinoma; low subtype; clear cell ... See more keywords
The Claudin-Low Subtype of High-Grade Serous Ovarian Carcinoma Exhibits Stem Cell Features
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DOI: 10.3390/cancers13040906
Abstract: Simple Summary Here, we identified and characterized a claudin-low subtype of high-grade serous ovarian cancer. This rare variant of undifferentiated neoplasm shares transcriptional features with the homonym subtype of breast cancer, including low epithelial differentiation,… read more here.
Keywords: grade serous; cell; high grade; claudin low ... See more keywords