Claudin targeting as an effective tool for directed barrier modulation of the viable epidermis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14879
Abstract: Tight junction (TJ) formation is vital for epidermal barrier function. We aimed to specifically manipulate TJ barriers in the reconstructed human epidermis (RHE) by claudin‐1 and ‐4 knockdown (KD) and by claudin‐binding fusion proteins of… read more here.
Keywords: gst ccpe; claudin; barrier; claudin targeting ... See more keywords
Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
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DOI: 10.3390/ijms20194774
Abstract: Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1). Cldn1 is a… read more here.
Keywords: cldn1; clostridium perfringens; ccpe; perfringens enterotoxin ... See more keywords