Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1498-2
Abstract: Mobile genetic elements involved in mediating horizontal transfer events contribute to bacterial evolution, and bacterial genomic plasticity and instability result in variation in functional genetic information in Streptomyces secondary metabolism. In a previous study, we… read more here.
Keywords: clavulanic acid; strain f613; streptomyces strain; transfer ... See more keywords
Amoxicillin–clavulanic acid induced sperm abnormalities and histopathological changes in mice
Sign Up to like & getrecommendations! Published in 2017 at "Asian pacific Journal of Tropical Biomedicine"
DOI: 10.1016/j.apjtb.2017.08.002
Abstract: Abstract Objective To explore the genotoxic potential and histopathological changes induced in liver, kidney, testis, brain and heart after using the antibiotic drug amoxicillin/clavulanic acid (4:1). Methods The study included chromosomal aberration analysis in bone-marrow… read more here.
Keywords: histopathological changes; clavulanic acid; treatment; abnormalities histopathological ... See more keywords
Purification of clavulanic acid produced by Streptomyces clavuligerus via submerged fermentation using polyethylene glycol/cholinium chloride aqueous two-phase systems
Sign Up to like & getrecommendations! Published in 2017 at "Fluid Phase Equilibria"
DOI: 10.1016/j.fluid.2017.07.005
Abstract: Abstract Clavulanic acid (CA) is an important pharmaceutical compound produced by batch fermentation of Streptomyces clavuligerus . Since, CA is chemically unstable, its downstream processing should be studied to develop more efficient and resolute techniques.… read more here.
Keywords: streptomyces clavuligerus; phase; clavulanic acid; peg 600 ... See more keywords
Amoxicillin-clavulanic acid-induced type II Kounis syndrome during general anaesthesia complicated with hypoxic-ischaemic encephalopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Revista espanola de anestesiologia y reanimacion"
DOI: 10.1016/j.redar.2019.06.002
Abstract: Anaphylaxis is a severe acute multisystem syndrome involving massive mediator release from mast cells (MCs) and basophils. Although the entire arterial system can be affected, when coronary arteries are the main targets, Kounis syndrome needs… read more here.
Keywords: acid induced; clavulanic acid; kounis; amoxicillin clavulanic ... See more keywords
Orally Absorbed Derivatives of the β-Lactamase Inhibitor Avibactam. Design of Novel Prodrugs of Sulfate Containing Drugs.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01389
Abstract: Only one FDA-approved β-lactamase inhibitor has ever been orally available: clavulanic acid, approved in 1984. Avibactam, approved by FDA in 2015, is the first of a new class of BLIs called diazabicyclooctanes, or "DBOs". This… read more here.
Keywords: inhibitor; clavulanic acid; lactamase inhibitor; orally absorbed ... See more keywords
Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c00231
Abstract: Background and Aim: Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is characterized as a multifaced disorder with a greater genetic contribution. The contribution of many genes such as… read more here.
Keywords: clavulanic acid; alzheimer disease; group; acid ... See more keywords
Neuroprotective effect of clavulanic acid on trimethyltin (TMT)-induced cytotoxicity in PC12 cells
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DOI: 10.1080/01480545.2018.1468772
Abstract: Abstract Trimethyltin (TMT) is a short-chain trialkyltin with various applications in industry. In addition, it is a known neurotoxin, producing significant and selective neurodegeneration in the limbic system of both human and animals. Recently, effect… read more here.
Keywords: tmt; pc12 cells; effect clavulanic; clavulanic acid ... See more keywords
Postreconstitution Stability of Amoxicillin-Clavulanic Acid Suspensions at Tropical Room Temperature.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piz021
Abstract: The storage conditions of reconstituted β-lactam suspensions are of concern, especially in tropical countries. Improper storage conditions after reconstitution lead to administration of a subtherapeutic dose of medication, which in turn leads to treatment failure… read more here.
Keywords: suspensions tropical; acid suspensions; amoxicillin clavulanic; clavulanic acid ... See more keywords
Linear IgA bullous dermatosis: A rare manifestation of amoxicillin‐clavulanic acid treatment
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DOI: 10.1111/dth.14187
Abstract: Dear Editor, A 27-old year woman with type 1 diabetes was admitted to our dermatology department with a 2-week history of nonpruritic vesiculobullous eruption involving skin and mucosa. The eruption occurred 6 days after receiving… read more here.
Keywords: clavulanic acid; acid treatment; amoxicillin clavulanic; linear iga ... See more keywords
Is the demonstration of bioequivalence for clavulanic acid required in amoxicillin–clavulanic acid orally administered immediate‐release products?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.12920
Abstract: Bioequivalence (BE) criteria for amoxicillin–clavulanic acid (Co‐amoxiclav) oral formulations are based on 90% confidence interval for both amoxicillin and clavulanic acid. The aim of this work is to explore the relevance of demonstrating BE of… read more here.
Keywords: demonstration bioequivalence; clavulanic acid; amoxicillin clavulanic; acid ... See more keywords
Effect of amoxicillin‐clavulanic acid on clinical scores, intestinal microbiome, and amoxicillin‐resistant Escherichia coli in dogs with uncomplicated acute diarrhea
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DOI: 10.1111/jvim.15775
Abstract: Abstract Background Despite limited evidence of efficacy, antibiotic treatment is still frequently prescribed in dogs with uncomplicated acute diarrhea (AD). Objective To assess whether amoxicillin‐clavulanic acid has a clinical benefit, an effect on the fecal… read more here.
Keywords: clinical scores; clavulanic acid; treatment; amoxicillin clavulanic ... See more keywords