Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32719
Abstract: The mammalian liver harbors heterogeneous cell types that communicate via local paracrine signaling. Recent studies have delineated the transcriptomic landscape of the liver in nonalcoholic steatohepatitis (NASH) that provides insights into liver cell heterogeneity, intercellular… read more here.
Keywords: induced nash; paracrine signaling; clcf1; diet induced ... See more keywords
Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22400-y
Abstract: The cytokines CLCF1 and CNTF are ligands for the CNTF receptor and the apolipoprotein E (ApoE) receptor sortilin. Both share structural similarities with the N-terminal domain of ApoE, known to bind CNTF. We therefore evaluated… read more here.
Keywords: effect human; cytokine; apoe; clcf1 activity ... See more keywords
Cardiotrophin-Like Cytokine Factor 1 Exhibits a Myeloid-Biased Hematopoietic-Stimulating Function
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02133
Abstract: Cardiotrophin-like cytokine factor 1 (CLCF1) is secreted as a complex with the cytokine receptor-like factor 1 (CRLF1). Syndromes caused by mutations in the genes encoding CLCF1 or CRLF1 suggest an important role for CLCF1 in… read more here.
Keywords: cardiotrophin like; cytokine; like cytokine; clcf1 ... See more keywords
CLCF1 Is a Novel Potential Immune-Related Target With Predictive Value for Prognosis and Immunotherapy Response in Glioma
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DOI: 10.3389/fimmu.2022.810832
Abstract: Background Cardiotrophin-like cytokine factor 1 (CLCF1) has been described as an oncogene and a potential therapeutic target in a variety of cancers, but its role in glioma remains unknown. Methods Based on The Cancer Genome… read more here.
Keywords: prognosis; immunotherapy; clcf1 expression; glioma ... See more keywords
CRLF1 and CLCF1 in Development, Health and Disease
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DOI: 10.3390/ijms23020992
Abstract: Cytokines and their receptors have a vital function in regulating various processes such as immune function, inflammation, haematopoiesis, cell growth and differentiation. The interaction between a cytokine and its specific receptor triggers intracellular signalling cascades… read more here.
Keywords: cytokine; crlf1 clcf1; clcf1 development; clcf1 ... See more keywords