CLDN1 induces autophagy to promote proliferation and metastasis of esophageal squamous carcinoma through AMPK/STAT1/ULK1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29133
Abstract: Tight junction is a structural constitution in cell–cell adhesion and play an important role in the maintenance of permeability and integrity of normal epithelial cell barrier. The protein encoded by Claudin 1 (CLDN1), a member… read more here.
Keywords: carcinoma; cldn1; proliferation metastasis; proliferation ... See more keywords
miR-29a suppresses growth and migration of hepatocellular carcinoma by regulating CLDN1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.110
Abstract: CLDN1 (claudin1) is essential for intercellular junctions and has been reported to be involving in cell migration and metastasis, making it as an oncogene in various cancer types. However, the biological function roles and regulatory… read more here.
Keywords: hepatocellular carcinoma; growth migration; cldn1; mir 29a ... See more keywords
Upregulation of hsa-miR-31-3p induced by ultraviolet affects keratinocytes permeability barrier by targeting CLDN1.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.113
Abstract: Chronic actinic dermatitis (CAD) is a photoallergic skin disease with complicated pathogenesis. However, skin barrier dysfunction may be involved according to clinical manifestation. To investigate the mechanism of CAD barrier dysfunction, noninvasive detection of skin… read more here.
Keywords: cldn1; hsa mir; mir; expression ... See more keywords
Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01982-17
Abstract: ABSTRACT Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in association with end-stage liver diseases. Investigations of the HCV life cycle have widened the knowledge of virology, and here we discovered that two piperazinylbenzenesulfonamides… read more here.
Keywords: hcv entry; cldn1; virology; hepatitis virus ... See more keywords
Abstract LB012: Claudin-1 is a driver and therapeutic target for cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb012
Abstract: Introduction: Cholangiocarcinoma (CCA) shows an alarming rise in incidence and mortality with unsatisfactory treatment options. Claudin-1 (CLDN1), a member of the tight junction family, is a transmembrane protein mediating cell stemness, plasticity and signaling. The… read more here.
Keywords: therapeutic target; cldn1; cca; cholangiocarcinoma ... See more keywords
Abstract LB050: BRAF V600E is associated with the upregulation of CLDN1 in thyroid cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-lb050
Abstract: Thyroid carcinoma is the most prevalent endocrine neoplasm. The most recurrent mutation in thyroid cancer (TC) is the V600E substitution in BRAF, which induces the over-activation of the MAPK pathway. The interaction between this pathway… read more here.
Keywords: braf v600e; cancer; cldn1; thyroid ... See more keywords
Abstract 7295: Reversing resistance to checkpoint inhibitors by treatment with claudin-1 specific antibodies in an orthotopic in vivo model for cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-7295
Abstract: Resistance to immunotherapy is a major challenge in the treatment of solid tumors. Cholangiocarcinoma (CCA) exemplifies this challenge by poor outcome and very limited response to approved checkpoint inhibitors (CPI). Claudin-1 (CLDN1) is a transmembrane… read more here.
Keywords: cancer; treatment; resistance; tumor ... See more keywords
Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2024.1347137
Abstract: Introduction Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, and has become a serious threat to public health. Intermittent hypoxia caused by OSA results in a low-grade inflammatory response that leads to impaired… read more here.
Keywords: cldn; cldn3; sleep apnea; cldn molecules ... See more keywords
CLDN1 Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205026
Abstract: Simple Summary Triple-negative breast cancer (TNBC) treatment represents a major challenge in oncology. TNBC evolves into chemotherapy resistance for 60 to 70% of the patients. About 77% of the TNBC displays a lack of claudin-1… read more here.
Keywords: breast cancer; cldn1; treatment; tnbc ... See more keywords
Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20194774
Abstract: Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1). Cldn1 is a… read more here.
Keywords: cldn1; clostridium perfringens; ccpe; perfringens enterotoxin ... See more keywords
Claudin-1 Contributes to Gastrointestinal Stromal Tumors (GIST) Resistance to Imatinib Mesylate (IM) via Regulation of FGFR-Signaling
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26178138
Abstract: We previously demonstrated that the activation of FGFR signaling in GIST may be a mechanism of GIST resistance to imatinib mesylate (IM). We show here that IM-resistant GIST cells lacking secondary KIT mutations overexpress claudin-1… read more here.
Keywords: gist; fgfr; fgfr signaling; cldn1 ... See more keywords