Abstract 2118: ABN501: A CLDN3-targeted monoclonal antibody with proven safety, pharmacokinetics, and synergistic anti-tumor efficacy
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DOI: 10.1158/1538-7445.am2025-2118
Abstract: ABN501 is an afucosylated monoclonal antibody specifically designed to target claudin-3 (CLDN3), a protein frequently overexpressed in various solid tumors, including small-cell lung cancer (SCLC). Given the critical role of CLDN3 in cancer cell proliferation… read more here.
Keywords: monoclonal antibody; cancer; abn501 cldn3; cldn3 ... See more keywords
Abstract 4807: Claudin-3-targeting CAR-T using C-terminal domain of Clostridium perfringens enterotoxin for TKI-resistant EGFR-mutated NSCLC
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DOI: 10.1158/1538-7445.am2025-4807
Abstract: Epidermal growth factor receptor (EGFR) mutations (MT) are oncogenic drivers in non-small cell lung cancer (NSCLC). However, acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) remains a significant challenge for the treatment of NSCLC. Claudin-3… read more here.
Keywords: egfr; cldn3; perfringens enterotoxin; car ... See more keywords
Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates
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DOI: 10.3389/fneur.2024.1347137
Abstract: Introduction Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder, and has become a serious threat to public health. Intermittent hypoxia caused by OSA results in a low-grade inflammatory response that leads to impaired… read more here.
Keywords: cldn; cldn3; sleep apnea; cldn molecules ... See more keywords
Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting
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DOI: 10.3390/biom10010051
Abstract: Most malignant tumors originate from epithelial tissues in which tight junctions mediate cell–cell interactions. Tight junction proteins, especially claudin-3 (CLDN3), are overexpressed in various cancers. Claudin-3 is exposed externally during tumorigenesis making it a potential… read more here.
Keywords: development human; cldn3; carcinoma; monoclonal antibody ... See more keywords
MiR-181a Negatively Regulates Claudin-3 to Facilitate Lateolabrax maculatus Iridovirus Replication in Lateolabrax maculatus Astroglia Cells
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DOI: 10.3390/v16101589
Abstract: Lateolabrax maculatus iridovirus (LMIV) is a variant strain of red sea bream iridovirus (RSIV), causing serious economic losses in aquaculture. Claudins (CLDNs) are major components of tight junctions (TJs) forming an important line of defense… read more here.
Keywords: replication; lateolabrax maculatus; mir 181a; cldn3 ... See more keywords