Abstract 1778: Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate
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DOI: 10.1158/1538-7445.am2018-1778
Abstract: Background Claudin 6 (CLDN6) is a tight junction membrane protein whose expression in normal tissue is confined to embryonic cells, but is aberrantly expressed in various human cancers. The anti-CLDN6 monoclonal antibody (mAb), IMAB027, has… read more here.
Keywords: imab027 vcmmae; vcmmae; cldn6; antitumor activity ... See more keywords
Abstract 2385: Discovery of highly specific claudin 6 monoclonal antibodies
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DOI: 10.1158/1538-7445.am2019-2385
Abstract: Claudin 6 (CLDN6) is an oncofetal tight junction protein involved in the cell-to-cell adhesion of epithelial and endothelial cell sheets. Although silenced in healthy adult human tissues, CLDN6 expression has been found in ovarian, gastric,… read more here.
Keywords: discovery; specific claudin; cldn6; highly specific ... See more keywords
SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells
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DOI: 10.3390/ijms18091863
Abstract: The downregulation of tight junction protein CLDN6 promotes breast cancer cell migration and invasion; however, the exact mechanism underlying CLDN6 downregulation remains unclear. CLDN6 silence is associated with DNA methyltransferase 1 (DNMT1) mediated DNA methylation,… read more here.
Keywords: migration invasion; methylation; cldn6; breast cancer ... See more keywords