Abstract 1778: Preclinical characterization of the safety and antitumor activity of IMAB027-vcMMAE, an anticlaudin 6 antibody-drug conjugate
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DOI: 10.1158/1538-7445.am2018-1778
Abstract: Background Claudin 6 (CLDN6) is a tight junction membrane protein whose expression in normal tissue is confined to embryonic cells, but is aberrantly expressed in various human cancers. The anti-CLDN6 monoclonal antibody (mAb), IMAB027, has… read more here.
Keywords: imab027 vcmmae; vcmmae; cldn6; antitumor activity ... See more keywords
Abstract 2385: Discovery of highly specific claudin 6 monoclonal antibodies
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DOI: 10.1158/1538-7445.am2019-2385
Abstract: Claudin 6 (CLDN6) is an oncofetal tight junction protein involved in the cell-to-cell adhesion of epithelial and endothelial cell sheets. Although silenced in healthy adult human tissues, CLDN6 expression has been found in ovarian, gastric,… read more here.
Keywords: discovery; specific claudin; cldn6; highly specific ... See more keywords
Abstract 6715: CLDN6: Biological insight into therapeutic potency of SAIL66, a next generation of T-cell engager targeting CLDN6
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DOI: 10.1158/1538-7445.am2024-6715
Abstract: Background: Because of high recurrence rate, ovarian cancer continues to demand new treatments. Recently, we have developed a next-generation T-cell engager SAIL66, which is a tri-specific monoclonal antibody designed to bind to CLDN6 on cancer… read more here.
Keywords: cancer; biology; ovarian cancer; cell ... See more keywords
Abstract 6750: QLS5132, a highly selective anti-CLDN6 ADC with broader therapeutic window
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DOI: 10.1158/1538-7445.am2025-6750
Abstract: Claudin-6 (CLDN6), a member of the claudin family, is localized in the tight junctions of epithelial cells to regulate permeability, barrier function and polarity of epithelial layers. CLDN6 is notably upregulated in multiple solid tumor… read more here.
Keywords: cancer; therapeutic window; adc; anti cldn6 ... See more keywords
Abstract 7325: Pharmacologic characterization of a highly specific and potent CLDN6xCD3 T cell engager (TCE), ARC101, for the treatment of CLDN6+ cancers
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DOI: 10.1158/1538-7445.am2025-7325
Abstract: Claudin 6 (CLDN6) is an oncofetal protein involved in tight junction formation and is responsible for regulating cell polarity, adhesion and permeability. CLDN6 has recently emerged as an ideal target for novel oncology therapeutics, given… read more here.
Keywords: cancer; arc101; cell; expression ... See more keywords
Clinicopathological Significance of Claudin-6 Immunoreactivity in Low-grade, Early-stage Endometrioid Endometrial Carcinoma
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DOI: 10.21873/invivo.13837
Abstract: Background/Aim: Dysregulation of claudin 6 (CLDN6) expression has been widely documented in various malignancies. CLDN6 is aberrantly expressed in many types of human carcinomas; however, its clinical significance in endometrial carcinoma has seldom been investigated.… read more here.
Keywords: stage; endometrial carcinoma; expression; cldn6 ... See more keywords
The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities
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DOI: 10.3390/cancers17060920
Abstract: Simple Summary The oncofetal membrane protein Claudin 6 (CLDN6) is an attractive target for CAR-T cells therapies. Detailed analysis of CLDN6 expression in normal tissues of children is lacking, limiting its use in pediatric trials.… read more here.
Keywords: cldn6 expression; pediatric solid; cell; target ... See more keywords
SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells
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DOI: 10.3390/ijms18091863
Abstract: The downregulation of tight junction protein CLDN6 promotes breast cancer cell migration and invasion; however, the exact mechanism underlying CLDN6 downregulation remains unclear. CLDN6 silence is associated with DNA methyltransferase 1 (DNMT1) mediated DNA methylation,… read more here.
Keywords: migration invasion; methylation; cldn6; breast cancer ... See more keywords
CLDN6 induces chemoresistance through protective autophagy in breast cancer
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DOI: 10.7150/ijbs.116340
Abstract: Protective autophagy, a defensive response of cancer cells to chemotherapeutic stress, plays a critical role in the development of chemoresistance. Our previous research has demonstrated that the tight junction protein Claudin-6 (CLDN6) can induce autophagy… read more here.
Keywords: cancer; breast cancer; chemoresistance; cldn6 ... See more keywords