Impact of the COVID‐19 Pandemic on Conduct and Results of CLEAR Outcomes Trial
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DOI: 10.1002/clc.24328
Abstract: The COVID‐19 pandemic disrupted clinical research. CLEAR Outcomes investigated the effect of bempedoic acid (BA) versus placebo in 13 970 patients with statin intolerance and high cardiovascular (CV) risk. BA reduced the risk of the primary… read more here.
Keywords: pandemic conduct; covid pandemic; clear outcomes; impact covid ... See more keywords
Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of Bempedoic acid on cardiovascular events in patients with statin intolerance.
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DOI: 10.1016/j.ahj.2020.10.060
Abstract: BACKGROUND Although statins play a pivotal role in the prevention of atherosclerotic cardiovascular disease, many patients fail to achieve recommended lipid levels due to statin-associated muscle symptoms. Bempedoic acid is an oral pro-drug that is… read more here.
Keywords: statin intolerance; clear outcomes; trial; bempedoic acid ... See more keywords
Red cell distribution width as a predictor of cardiovascular events in high-risk patients with statin intolerance: post-hoc analysis of the CLEAR Outcomes trial
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DOI: 10.1093/eurheartj/ehae666.2738
Abstract: Despite optimal lipid-lowering therapy there is up to 70% residual risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events, motivating further testing of alternative risk factors and disease pathways. Red cell distribution width (RDW) is a… read more here.
Keywords: clear outcomes; risk; rdw; cell ... See more keywords