Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing -- Proof of concept for virus filtration.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28119
Abstract: The development of continuous/connected bioprocesses requires new approaches for viral clearance validation, both for specific unit operations and for the overall process. In this study, we have developed a transient inline spiking system that can… read more here.
Keywords: transient inline; virus clearance; inline spiking; virus ... See more keywords
Prevention of lymphoedema after axillary clearance by external compression sleeves PLACE randomised trial results. Effects of high BMI
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5378
Abstract: Around 25% of women undergoing Axillary Clearance (ANC) develop lymphedema (LE). Intervention with a compression garment is recommended to prevent LE but no randomised evidence exists to support this strategy. read more here.
Keywords: clearance; prevention lymphoedema; axillary clearance; clearance external ... See more keywords
Early posttherapy clearance of human papillomavirus and treatment response in cervical carcinoma.
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DOI: 10.1002/cncr.33040
Abstract: BACKGROUND Among patients with cervical cancer, little is known about the significance of persistent human papillomavirus (HPV) expression after chemoradiation (CRT). This study evaluated associations between early posttreatment HPV clearance and patient outcomes with an… read more here.
Keywords: early posttherapy; posttherapy; hpv; clearance ... See more keywords
Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
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DOI: 10.1002/cpt.2052
Abstract: The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine… read more here.
Keywords: elderly subjects; 11c metoclopramide; clearance; brain ... See more keywords
Urinary Clearance of 11-Nor-9-Carboxy-Δ9 -Tetrahydrocannabinol (THCCOOH): A Detailed Pharmacokinetic Analysis.
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DOI: 10.1002/dta.3259
Abstract: BACKGROUND Urine is a common matrix for screening for cannabis use. Urine assays typically measure total THCCOOH concentrations after hydrolysis cleaves the glucuronide. Urine THCCOOH concentration is adjusted by urine creatinine concentration or specific gravity,… read more here.
Keywords: clearance; urinary clearance; thccooh; concentration ... See more keywords
Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ+TNF‐α+CD4+T cells: Impact of PD‐1 inhibition in active tuberculosis patients
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948283
Abstract: Prolonged therapy, drug toxicity, noncompliance, immune suppression, and alarming emergence of drug resistance necessitate the search for therapeutic vaccine strategies for tuberculosis (TB). Such strategies ought to elicit not only IFN‐γ, but polyfunctional response including… read more here.
Keywords: active tuberculosis; inhibition; tuberculosis patients; impact inhibition ... See more keywords
E6020, a synthetic TLR4 agonist, accelerates myelin debris clearance, Schwann cell infiltration, and remyelination in the rat spinal cord
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23132
Abstract: Oligodendrocyte progenitor cells (OPCs) are present throughout the adult brain and spinal cord and can replace oligodendrocytes lost to injury, aging, or disease. Their differentiation, however, is inhibited by myelin debris, making clearance of this… read more here.
Keywords: synthetic tlr4; cord; myelin debris; tlr4 agonist ... See more keywords
Astrocyte‐selective STAT3 knockdown rescues methamphetamine withdrawal‐disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1
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DOI: 10.1002/glia.24046
Abstract: Methamphetamine (METH) is a common abused drug. METH‐triggered glutamate (Glu) levels in dorsal CA1 (dCA1) could partially explain the etiology of METH‐caused abnormal memory, but the synaptic mechanism remains unclear. Here, we found that METH… read more here.
Keywords: capacity; glu; clearance; withdrawal ... See more keywords
In vivo imaging of the phagocytic dynamics underlying efficient clearance of adult-born hippocampal granule cells by ramified microglia.
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DOI: 10.1002/glia.24379
Abstract: The phagocytosis of dead cells by microglia is essential in brain development and homeostasis. However, the mechanism underlying the efficient removal of cell corpses by ramified microglia remains poorly understood. Here, we investigated the phagocytosis… read more here.
Keywords: clearance; cell; underlying efficient; ramified microglia ... See more keywords
Fecal microbiota transplantation induces hepatitis B virus e‐antigen (HBeAg) clearance in patients with positive HBeAg after long‐term antiviral therapy
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29008
Abstract: For hepatitis B virus (HBV) e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients, HBeAg seroconversion is a prerequisite for a definite course of antiviral treatment. Unfortunately, for both entecavir (ETV) and tenofovir disoproxil fumarate (TDF), HBeAg… read more here.
Keywords: antigen hbeag; antiviral therapy; microbiota; hepatitis virus ... See more keywords
Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.
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DOI: 10.1002/hep.32289
Abstract: BACKGROUND AND AIMS LPS clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear. APPROACH AND RESULTS… read more here.
Keywords: mice; bsep; clearance; liver injury ... See more keywords