Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400149
Abstract: Alzheimer's disease (AD) poses a significant burden on the economy and healthcare systems worldwide. Although the pathophysiology of AD remains debatable, its progression is strongly correlated with the accumulation of tau aggregates. Therefore, tau clearance… read more here.
Keywords: alzheimer disease; neurotransmitter derived; therapy; tau clearance ... See more keywords
Polyphenol Mediated Assembly: Tailored Nano‐Dredger Unblocks Axonal Autophagosomes Retrograde Transport Traffic Jam for Accelerated Alzheimer's Waste Clearance
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202413614
Abstract: Clear‐cut evidence has linked defective autophagy to Alzheimer's disease (AD). Recent studies underscore a unique hurdle in AD neuronal autophagy: impaired retrograde axonal transport of autophagosomes, potent enough to induce autophagic stress and neurodegeneration. Nonetheless,… read more here.
Keywords: transport; retrograde transport; nano dredger; clearance ... See more keywords
Unique Dual-Affinity Strategy for Specific Lipopolysaccharide Clearance in Sepsis Therapy: Peptide-Conjugated Molecularly Imprinted Polymers via Emulsion Interfacial Polymerization.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202517135
Abstract: Sepsis is an infection-induced organ dysfunction with high global morbidity and mortality. Specific clearance of lipopolysaccharides (LPSs), key pathological drivers in sepsis, from the bloodstream is critical for effective therapy. However, selective capture of LPS… read more here.
Keywords: imprinted polymers; therapy; clearance; dual affinity ... See more keywords
Development and Evaluation of User‐Friendly Modeled Approach for Sustainable Polymer Membranes for Advanced Hemodialysis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202400435
Abstract: Hemodialysis is crucial for patients with end‐stage renal disease, yet evaluating its operating parameters often requires complex mathematical models. To simplify this process, user‐friendly modules have been developed to accurately assess key parameters with minimal… read more here.
Keywords: min; clearance; polymer; user friendly ... See more keywords
Very Low‐Intensity Ultrasound Facilitates Glymphatic Influx and Clearance via Modulation of the TRPV4‐AQP4 Pathway
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DOI: 10.1002/advs.202401039
Abstract: Recently, the glymphatic system has been proposed as a mechanism for waste clearance from the brain parenchyma. Glymphatic dysfunction has previously been shown to be associated with several neurological diseases, including Alzheimer's disease, traumatic brain… read more here.
Keywords: intensity ultrasound; brain; low intensity; glymphatic influx ... See more keywords
Development of a transient inline spiking system for evaluating virus clearance in continuous bioprocessing -- Proof of concept for virus filtration.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28119
Abstract: The development of continuous/connected bioprocesses requires new approaches for viral clearance validation, both for specific unit operations and for the overall process. In this study, we have developed a transient inline spiking system that can… read more here.
Keywords: transient inline; virus clearance; inline spiking; virus ... See more keywords
Prevention of lymphoedema after axillary clearance by external compression sleeves PLACE randomised trial results. Effects of high BMI
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5378
Abstract: Around 25% of women undergoing Axillary Clearance (ANC) develop lymphedema (LE). Intervention with a compression garment is recommended to prevent LE but no randomised evidence exists to support this strategy. read more here.
Keywords: clearance; prevention lymphoedema; axillary clearance; clearance external ... See more keywords
Early posttherapy clearance of human papillomavirus and treatment response in cervical carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33040
Abstract: BACKGROUND Among patients with cervical cancer, little is known about the significance of persistent human papillomavirus (HPV) expression after chemoradiation (CRT). This study evaluated associations between early posttreatment HPV clearance and patient outcomes with an… read more here.
Keywords: early posttherapy; posttherapy; hpv; clearance ... See more keywords
Impaired Clearance From the Brain Increases the Brain Exposure to Metoclopramide in Elderly Subjects
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DOI: 10.1002/cpt.2052
Abstract: The antiemetic and gastroprokinetic drug metoclopramide is a weak substrate of the blood‐brain barrier (BBB) efflux transporter P‐gp and displays central nervous system (CNS) side effects (i.e., extrapyramidal symptoms and tardive dyskinesia) caused by dopamine… read more here.
Keywords: elderly subjects; 11c metoclopramide; clearance; brain ... See more keywords
Urinary Clearance of 11-Nor-9-Carboxy-Δ9 -Tetrahydrocannabinol (THCCOOH): A Detailed Pharmacokinetic Analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3259
Abstract: BACKGROUND Urine is a common matrix for screening for cannabis use. Urine assays typically measure total THCCOOH concentrations after hydrolysis cleaves the glucuronide. Urine THCCOOH concentration is adjusted by urine creatinine concentration or specific gravity,… read more here.
Keywords: clearance; urinary clearance; thccooh; concentration ... See more keywords
Improved Mycobacterium tuberculosis clearance after the restoration of IFN‐γ+TNF‐α+CD4+T cells: Impact of PD‐1 inhibition in active tuberculosis patients
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948283
Abstract: Prolonged therapy, drug toxicity, noncompliance, immune suppression, and alarming emergence of drug resistance necessitate the search for therapeutic vaccine strategies for tuberculosis (TB). Such strategies ought to elicit not only IFN‐γ, but polyfunctional response including… read more here.
Keywords: active tuberculosis; inhibition; tuberculosis patients; impact inhibition ... See more keywords