Pulmonary exacerbations, airway pathogens, and long‐term course of lung clearance index in children and young adults with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.26136
Abstract: Pulmonary exacerbations (PEx), pathogens colonizing the respiratory tract, and patients' age are associated with progressive worsening of lung function among patients with cystic fibrosis (CF). However, the effect of these factors on longitudinal changes of… read more here.
Keywords: cystic fibrosis; lung clearance; clearance index; pulmonary exacerbations ... See more keywords
Abnormal Lung Clearance Index in Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID) Children with Otherwise Normal FEV1
Sign Up to like & getrecommendations! Published in 2019 at "Lung"
DOI: 10.1007/s00408-019-00307-3
Abstract: In preschool children with cystic fibrosis (CF), lung clearance index (LCI) is a sensitive test to detect early lung disease. Some children with CF screen positive, inconclusive diagnosis (CFSPID) may in time develop clinical features… read more here.
Keywords: cystic fibrosis; lung clearance; diagnosis; clearance index ... See more keywords
Utility of Lung Clearance Index Testing as a Noninvasive Marker of Deployment-related Lung Disease
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DOI: 10.1097/jom.0000000000001058
Abstract: Objective: The aim of this study was to determine utility and sensitivity of lung clearance index (LCI) testing as a marker of lung injury in symptomatic military deployers compared with healthy controls. Methods: We tested… read more here.
Keywords: clearance index; lung clearance; lung disease; lung ... See more keywords
S70 Change in lung clearance index and exhaled nitric oxide as markers of systemic corticosteroid response in children with severe asthma
Sign Up to like & getrecommendations! Published in 2017 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210983.76
Abstract: Introduction Children with severe therapy resistant asthma (STRA) have heterogeneous disease with variable response to steroids. Currently, spirometry (forced expiratory volume in 1 s (FEV1)) is most widely used to assess treatment response. We hypothesised lung… read more here.
Keywords: lung clearance; response; clearance index; systemic corticosteroid ... See more keywords
Lung clearance index predicts pulmonary exacerbations in individuals with primary ciliary dyskinesia: a multicentre cohort study
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DOI: 10.1136/thoraxjnl-2020-215504
Abstract: Background Lung clearance index (LCI) is a promising lung function outcome in individuals with primary ciliary dyskinesia (PCD). The impact of events clinically important for individuals with PCD, such as pulmonary exacerbations, on LCI is… read more here.
Keywords: lung clearance; primary ciliary; ciliary dyskinesia; clearance index ... See more keywords
Longitudinal lung clearance index and association with structural lung damage in children with cystic fibrosis
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DOI: 10.1136/thoraxjnl-2021-218178
Abstract: Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden Departmemt of Mathematical Science, Chalmers University of Technology, Gothenburg, Sweden Department of Pediatrics, Central Hospital, Skoevde, Sweden Department of… read more here.
Keywords: lung; lung clearance; department; clearance index ... See more keywords
Evaluation of clinically relevant changes in the lung clearance index in children with cystic fibrosis and healthy controls
Sign Up to like & getrecommendations! Published in 2022 at "Thorax"
DOI: 10.1136/thoraxjnl-2021-218347
Abstract: Background The limits of reproducibility of the lung clearance index (LCI) are higher in children with cystic fibrosis (CF) compared with healthy children, and it is currently unclear what defines a clinically meaningful change. Methods… read more here.
Keywords: healthy controls; children cystic; cystic fibrosis; lung clearance ... See more keywords
Nitrogen-based lung clearance index: a valid physiological biomarker for the clinic.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00511.2021
Abstract: Multiple breath washout (MBW) testing is increasingly used as a physiological measurement in the clinic, due in part to the availability of commercial equipment and reference values for MBW indices. Commercial N2 washout devices are… read more here.
Keywords: concentration; lung clearance; clearance index; clinic ... See more keywords
Longitudinal course of clinical lung clearance index in children with cystic fibrosis
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DOI: 10.1183/13993003.02686-2020
Abstract: Background Although the lung clearance index (LCI) is a sensitive marker of small airway disease in individuals with cystic fibrosis (CF), less is known about longitudinal changes in LCI during routine clinical surveillance. Here, our… read more here.
Keywords: lung clearance; lci; clearance index; routine clinical ... See more keywords
Longitudinal course of clinically measured lung clearance index in children with cystic fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2020.4312
Abstract: Background: While lung clearance index (LCI) is acknowledged to be a sensitive measure to detect small airway disease in cystic fibrosis (CF), less is known about its long-term progression. For clinical interpretation, knowledge of longitudinal… read more here.
Keywords: cystic fibrosis; lung clearance; clearance index;
Lung Clearance Index May Detect Early Peripheral Lung Disease in Sickle Cell Anemia.
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DOI: 10.1513/annalsats.202102-168oc
Abstract: RATIONALE Chronic lung injury is common in sickle cell anemia (SCA) and worsens outcomes. Sensitive lung function tests might predict reversible disease that might benefit from therapeutic interventions. OBJECTIVE To evaluate whether Lung Clearance Index… read more here.
Keywords: disease; lung; lung clearance; clearance index ... See more keywords