Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
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DOI: 10.1124/dmd.122.000836
Abstract: Quantitative assessment of hepatic clearance (CLH) of drugs is critical to accurately predict human dose and drug-drug interaction (DDI) liabilities. This is challenging for drugs that involve complex transporter-enzyme interplay. In this study, we demonstrate… read more here.
Keywords: clearance; pevonedistat; clearance model; ddi ... See more keywords