Molecular Nanoparticles of Ferric-Tannic Complexes Enhance Brain Magnetic Resonance Imaging and Activate Brain Clearance Pathways.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00719
Abstract: Iron-containing drugs can be considered beneficial for noninvasive magnetic resonance imaging (MRI) and induction of essential biochemical processes. Herein, we present a new type of iron-containing drug based on molecular nanoparticles of ferric-tannic complexes (FTs),… read more here.
Keywords: clearance; magnetic resonance; resonance imaging; brain ... See more keywords
Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03394c
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc03394c
Abstract: Appetite for ubiquitin: a gushy travel companion in the intracellular journey of the amyloid β peptide. read more here.
Keywords: amyloid peptide; peptide interferes; clearance pathways; ubiquitin binds ... See more keywords
Targeting protein clearance pathways in GBA1-associated Parkinson disease
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DOI: 10.1080/14728222.2022.2166828
Abstract: The clearance of damaged and unwanted proteins is essential for maintaining cellular homeostasis [1]. The two main mechanisms for the degradation of misfolded or aggregated proteins within the cell are the ubiquitin-proteasome system (UPS) and… read more here.
Keywords: clearance; gcase; parkinson disease; clearance pathways ... See more keywords
Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways
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DOI: 10.1371/journal.pone.0182895
Abstract: Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer’s disease (AD). Protein degradation through the proteasome pathway decreases with age and in AD brains, and the Aβ42 peptide has been shown… read more here.
Keywords: clearance pathways; protein clearance; activity; pathology ... See more keywords
Clearance pathways of near-infrared-II contrast agents
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DOI: 10.7150/thno.79209
Abstract: Near-infrared-II (NIR-II) bioimaging gradually becomes a vital visualization modality in the real-time investigation for fundamental biological research and clinical applications. The favorable NIR-II contrast agents are vital in NIR-II imaging technology for clinical translation, which… read more here.
Keywords: clearance; contrast; contrast agents; near infrared ... See more keywords