Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver
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DOI: 10.1080/00498254.2019.1664791
Abstract: Abstract 1. Immunodeficient chimeric mice with humanised liver have been useful in predicting total clearance values of drugs in humans. However, their usefulness may currently be limited for specific compounds with interspecies differences. 2. In… read more here.
Keywords: clearance values; hepatic intrinsic; total clearance; humanised liver ... See more keywords