Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis.
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DOI: 10.1039/c8cc04981e
Abstract: An analogue of the bacterial siderophore desferrioxamine B (DFOB) containing a disulfide motif in the backbone was produced from Streptomyces pilosus cultures supplemented with cystamine. Cystamine competed against native 1,5-diaminopentane during assembly. DFOB-(SS)1[001] and its… read more here.
Keywords: disulfide bond; siderophore; natural product; bond natural ... See more keywords