Porous silicon nanocarriers with stimulus-cleavable linkers for effective cancer therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202200076
Abstract: Porous silicon nanoparticles (pSiNPs) have been widely utilized as drug carriers due to their excellent biocompatibility, large surface area and versatile surface chemistry. However, the dispersion in pore size and biodegradability of pSiNPs arguably have… read more here.
Keywords: cleavable linkers; drug; stimulus cleavable; dox ... See more keywords
Enzymological Characterization of 64Cu-Labeled Neprilysin Substrates and Their Application for Modulating the Renal Clearance of Targeted Radiopharmaceuticals.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01472
Abstract: The applicability of radioligands for targeted endoradionuclide therapy is limited due to radiation-induced toxicity to healthy tissues, in particular to the kidneys as primary organs of elimination. The targeting of enzymes of the renal brush… read more here.
Keywords: cleavable linkers; labeled neprilysin; 64cu labeled; enzymological characterization ... See more keywords
Evaluation of Chemically-Cleavable Linkers for Quantitative Mapping of Small Molecule-Cysteinome Reactivity.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00424
Abstract: Numerous reagents have been developed to enable chemical proteomic analysis of small molecule-protein interactomes. However, the performance of these reagents has not been systematically evaluated and compared. Herein, we report our efforts to conduct a… read more here.
Keywords: cysteine residues; small molecule; chemically cleavable; linker ... See more keywords
Synthesis and radiolabelling of PSMA-targeted derivatives containing GYK/MVK cleavable linkers
Sign Up to like & getrecommendations! Published in 2023 at "Royal Society Open Science"
DOI: 10.1098/rsos.220950
Abstract: Targeted radionuclide therapy (TRT) is a promising strategy to treat different types of cancer. TRT relies on a targeting vector used to deliver a therapeutic radionuclide specifically to the tumour site. Several low molecular weight… read more here.
Keywords: cleavable linkers; synthesis radiolabelling; gyk; radiolabelling psma ... See more keywords
Application of Cleavable Linkers to Improve Therapeutic Index of Radioligand Therapies
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154959
Abstract: Radioligand therapy (RLT) is an emergent drug class for cancer treatment. The dose administered to cancer patients is constrained by the radiation exposure to normal tissues to maintain an appropriate therapeutic index. When a radiopharmaceutical… read more here.
Keywords: cleavable linkers; application cleavable; therapeutic index; linkers improve ... See more keywords