Catalyst-free Cleavage of Amide and C-O Double Bond for the Diastereoselective Synthesis of Trifluoromethyl-Containing Dihydrooxazole Derivatives.
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DOI: 10.1021/acs.orglett.9b00522
Abstract: A novel and efficient cascade method has been developed for the diastereoselective preparation of trifluoromethyl-containing dihydrooxazoles in high yields. The reaction was applicable to electron-deficient, electron-rich arenes, heteroarenes, and alkyl groups. Control experiments were conducted… read more here.
Keywords: cleavage amide; free cleavage; trifluoromethyl containing; reaction ... See more keywords