Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity
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DOI: 10.1038/s41467-018-06813-x
Abstract: Mutations of the intramembrane protease presenilin (PS) or of its main substrate, the amyloid precursor protein (APP), cause early-onset form of Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery without… read more here.
Keywords: cleavage app; mediated cleavage; presenilin mediated; app ... See more keywords