Emerging roles of alternative cleavage and polyadenylation (APA) in human disease.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30549
Abstract: In the messenger RNA (mRNA) maturation process, the 3'-end of pre-mRNA is cleaved and a poly(A) sequence is added, this is an important determinant of mRNA stability and its cellular functions. More than 60%-70% of… read more here.
Keywords: cleavage polyadenylation; polyadenylation apa; polyadenylation; alternative cleavage ... See more keywords
Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.094
Abstract: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance. We identified factors that form heterochromatin using dense profiles… read more here.
Keywords: polyadenylation factors; heterochromatin; cleavage polyadenylation; integration ... See more keywords
A compensatory link between cleavage/polyadenylation and mRNA turnover regulates steady-state mRNA levels in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121488119
Abstract: Significance Cells coordinate the rates of major biological processes in response to environmental conditions such as nutrient availability and temperature. Coordination mechanisms in which effects on one process are compensated for by effects on another… read more here.
Keywords: compensatory link; cleavage polyadenylation; mrna; polyadenylation ... See more keywords
Alternative polyadenylation factors link cell cycle to migration
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology"
DOI: 10.1186/s13059-018-1551-9
Abstract: BackgroundIn response to a wound, fibroblasts are activated to migrate toward the wound, to proliferate and to contribute to the wound healing process. We hypothesize that changes in pre-mRNA processing occurring as fibroblasts enter the… read more here.
Keywords: cleavage polyadenylation; quiescent fibroblasts; cell cycle; polyadenylation ... See more keywords
Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2021-0039
Abstract: Background: Recent studies have shown that cleavage and polyadenylation-specific factor 3 (CPSF3) is a promising antitumor therapeutic target, but its potential role in hepatocellular carcinoma (HCC) has not been reported. Materials & methods: We explored… read more here.
Keywords: cleavage polyadenylation; hcc; group; specific factor ... See more keywords