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   Articles with "cleavage sites" as a keyword



Possible cleavage sites of glutelin partial degradation confirmed by immunological analysis in globulin‐less mutants of rice (Oryza sativa L.)

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recommendations! Published in 2017 at "ELECTROPHORESIS"

DOI: 10.1002/elps.201700195

Abstract: Proteolytic cleavage or partial degradation of proteins is one of the important post‐translational modifications for various biological processes, but it is difficult to analyze. Previously, we demonstrated that some subunits of the major rice (Oryza… read more here.

Keywords: partial degradation; seed; cleavage; cleavage sites ... See more keywords

PCPS: A Web Server to Predict Proteasomal Cleavage Sites.

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recommendations! Published in 2020 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0389-5_23

Abstract: The proteasome complex is mainly responsible for proteolytic degradation of cytosolic proteins, generating the C-terminus of MHC I-restricted peptide ligands and CD8 T cell epitopes. Therefore, prediction of proteasomal cleavage sites is relevant for anticipating… read more here.

Keywords: proteasomal cleavage; cleavage; proteasome; pcps web ... See more keywords

Identification of Proteolytic Cleavage Sites of EphA2 by Membrane Type 1 Matrix Metalloproteinase on the Surface of Cancer Cells.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7595-2_3

Abstract: Proteolytic cleavage of membrane proteins can alter their functions depending on the cleavage sites. We recently demonstrated that membrane type 1 matrix metalloproteinase (MT1-MMP ) converts the tumor suppressor EphA2 into an oncogenic signal transducer… read more here.

Keywords: proteolytic cleavage; cleavage; membrane type; type matrix ... See more keywords

Comprehensive analysis of mRNA internal cleavage sites in Arabidopsis thaliana.

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recommendations! Published in 2018 at "Journal of bioscience and bioengineering"

DOI: 10.1016/j.jbiosc.2017.12.022

Abstract: The major obstacle of efficient transgene expression seems to be gene silencing, and one of the important factors in gene silencing is mRNA stability. Regulation of mRNA stability is an important aspect of the control… read more here.

Keywords: cleavage; internal cleavage; mrna internal; comprehensive analysis ... See more keywords

Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.03.013

Abstract: MicroRNA (miRNA) maturation is initiated by DROSHA, a double-stranded RNA (dsRNA)-specific RNase III enzyme. By cleaving primary miRNAs (pri-miRNAs) at specific positions, DROSHA serves as a main determinant of miRNA sequences and a highly selective… read more here.

Keywords: mirna; drosha cleavage; fclip; cleavage sites ... See more keywords

Precise Enzymatic Cleavage Sites for Improved Bioactivity of siRNA Lipo-Polyplexes.

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recommendations! Published in 2018 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.8b00585

Abstract: Sequence-defined cationic lipo-oligomers are potent siRNA carriers, forming stable lipo-polyplexes based on both electrostatic and hydrophobic interactions and, after endocytosis and endosomal protonation, facilitating the delivery of siRNA into the cytosol. After completion of the… read more here.

Keywords: lipo oligomers; cleavage; cleavage sites; enzymatic cleavage ... See more keywords
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Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics.

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recommendations! Published in 2019 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.9b00325

Abstract: Snakebite is a major medical concern in many parts of the world with metalloproteases playing important roles in the pathological effects of Viperidae venoms, including local tissue damage, hemorrhage and coagulopathy. Hemorrhagic Factor 3 (HF3),… read more here.

Keywords: hf3; cleavage; metalloprotease; cleavage sites ... See more keywords

Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-25796-w

Abstract: SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over 170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and vaccinate against this pathogen all benefit from an improved… read more here.

Keywords: proteolysis; cov replication; cleavage; infection ... See more keywords

Repression of apelin Furin cleavage sites provides antimetastatic strategy in colorectal cancer

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recommendations! Published in 2025 at "EMBO Molecular Medicine"

DOI: 10.1038/s44321-025-00196-5

Abstract: The adipokine apelin has been directly implicated in various physiological processes during embryogenesis and human cancers. Nevertheless, the importance of the conversion of its precursor proapelin to mature apelin in tumorigenesis remains unknown. In this… read more here.

Keywords: colorectal cancer; proapelin cleavage; cleavage sites; apelin ... See more keywords

More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites

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recommendations! Published in 2020 at "Molecular Biology of the Cell"

DOI: 10.1091/mbc.e20-08-0524

Abstract: Most mitochondrial proteins are synthesized as precursors that carry N-terminal presequences. After they are imported into mitochondria, these targeting signals are cleaved off by the mitochondrial processing peptidase (MPP). Using the mitochondrial tandem protein Arg5,6… read more here.

Keywords: processing peptidase; precursor; mitochondrial processing; cleavage sites ... See more keywords

PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy

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recommendations! Published in 2018 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btx670

Abstract: Summary Proteases are enzymes that specifically cleave the peptide backbone of their target proteins. As an important type of irreversible post-translational modification, protein cleavage underlies many key physiological processes. When dysregulated, proteases' actions are associated… read more here.

Keywords: cleavage; throughput prediction; cleavage sites; substrate ... See more keywords