A potential mechanism underlying U1 snRNP inhibition of the cleavage step of mRNA 3' processing.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.092
Abstract: It is well established that U1 snRNP inhibits the cleavage of cryptic polyadenylation site (PAS) within introns, thereby facilitating full-length mRNA transcription for numerous genes in vertebrate cells, yet the underlying mechanism remains poorly understood.… read more here.
Keywords: mrna processing; cleavage step; mechanism; step mrna ... See more keywords
Pressure modulates the self-cleavage step of the hairpin ribozyme
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14661
Abstract: The ability of certain RNAs, denoted as ribozymes, to not only store genetic information but also catalyse chemical reactions gave support to the RNA world hypothesis as a putative step in the development of early… read more here.
Keywords: cleavage step; step; hairpin ribozyme; self cleavage ... See more keywords