Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02680-4
Abstract: Soluble forms of platelet membrane proteins are released upon platelet activation. We previously reported that soluble C-type lectin-like receptor 2 (sCLEC-2) is released as a shed fragment (Shed CLEC-2) or as a whole molecule associated… read more here.
Keywords: clec; increased plasma; acute coronary; coronary syndrome ... See more keywords
The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15584-3
Abstract: Acetaminophen (APAP) is the main cause of acute liver failure in the West. Specific efficacious therapies for acute liver failure (ALF) are limited and time-dependent. The mechanisms that drive irreversible acute liver failure remain poorly characterized.… read more here.
Keywords: clec; liver failure; acute liver; liver ... See more keywords
Katacine Is a New Ligand of CLEC-2 that Acts as a Platelet Agonist
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-1772-1069
Abstract: Background CLEC-2 is a platelet receptor with an important role in thromboinflammation but a minor role in hemostasis. Two endogenous ligands of CLEC-2 have been identified, the transmembrane protein podoplanin and iron-containing porphyrin hemin, which… read more here.
Keywords: clec; ligand clec; new ligand; katacine new ... See more keywords
CLEC-2 Supports Platelet Aggregation in Mouse but not Human Blood at Arterial Shear
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-1896-6992
Abstract: C-type lectin-like receptor 2 (CLEC-2) is highly expressed on platelets and a subpopulation of myeloid cells, and is critical in lymphatic development. CLEC-2 has been shown to support thrombus formation at sites of inflammation, but… read more here.
Keywords: platelet; blood; clec; gpib cre ... See more keywords
Significant Hypo-Responsiveness to GPVI and CLEC-2 Agonists in Pre-Term and Full-Term Neonatal Platelets and following Immune Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0038-1646924
Abstract: Neonatal platelets are hypo-reactive to the tyrosine kinase-linked receptor agonist collagen. Here, we have investigated whether the hypo-responsiveness is related to altered levels of glycoprotein VI (GPVI) and integrin α2β1, or to defects in downstream… read more here.
Keywords: neonatal platelets; term; clec; gpvi clec ... See more keywords
Physiologic and pathophysiologic roles of interaction between C‐type lectin‐like receptor 2 and podoplanin: partners from in utero to adulthood
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13590
Abstract: A platelet activation receptor, C‐type lectin‐like receptor 2 (CLEC‐2), has been identified as a receptor for a platelet‐activating snake venom, rhodocytin. CLEC‐2 protein is highly expressed in platelets/megakaryocytes, and at lower levels in liver Kupffer… read more here.
Keywords: clec; podoplanin; type lectin; interaction ... See more keywords
Abstract 3259: CLEC-1 is a novel myeloid immune checkpoint for cancer immunotherapy controlling damaged and tumor cells phagocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-3259
Abstract: Myeloid cells represent one of the most abundant immune cell types in solid tumors and are generally associated with poor clinical outcome. We previously identified the orphan C-type lectin receptors (CLRs) CLEC-1 as over-expressed in… read more here.
Keywords: clec; tumor cells; cancer; myeloid ... See more keywords
CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-03-771907
Abstract: C-type lectin-like receptor 2 (CLEC-2) is a platelet receptor that is critical during development in blood-lymph separation and implicated in thrombus stability in thrombosis and hemostasis. It is the only known platelet activatory receptor that… read more here.
Keywords: clec; contributes hemostasis; hemostasis; hemitam signaling ... See more keywords