An intrinsically disordered protein region encoded by the human disease gene CLEC16A regulates mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2080383
Abstract: ABSTRACT CLEC16A regulates mitochondrial health through mitophagy and is associated with over 20 human diseases. However, the key structural and functional regions of CLEC16A, and their relevance for human disease, remain unknown. Here, we report… read more here.
Keywords: intrinsically disordered; human disease; protein region; clec16a ... See more keywords
The Autoimmune Disorder Susceptibility Gene CLEC16A Restrains NK Cell Function in YTS NK Cell Line and Clec16a Knockout Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00068
Abstract: CLEC16A locus polymorphisms have been associated with several autoimmune diseases. We overexpressed CLEC16A in YTS natural killer (NK) cells and observed reduced NK cell cytotoxicity and IFN-γ release, delayed dendritic cell (DC) maturation, decreased conjugate… read more here.
Keywords: clec16a; clec16a restrains; clec16a knockout; cell function ... See more keywords
CLEC16A—An Emerging Master Regulator of Autoimmunity and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098224
Abstract: CLEC16A is emerging as an important genetic risk factor for several autoimmune disorders and for Parkinson disease (PD), opening new avenues for translational research and therapeutic development. While the exact role of CLEC16A in health… read more here.
Keywords: clec16a emerging; clec16a; neurodegeneration; autoimmunity neurodegeneration ... See more keywords