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   Articles with "clec5a" as a keyword



CLEC5a-directed bispecific antibody for effective cellular phagocytosis

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recommendations! Published in 2022 at "mAbs"

DOI: 10.1080/19420862.2022.2040083

Abstract: ABSTRACT While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we describe… read more here.

Keywords: bispecific antibody; cellular phagocytosis; clec5a; phagocytosis ... See more keywords

TMIC-27. PDPN ACTIVATION OF CLEC5A IN THE PERI-NECROTIC NICHE DRIVES TAM POLARIZATION AND TME IMMUNOSUPPRESSION IN GLIOBLASTOMA

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae165.1205

Abstract: Glioblastoma, IDH-wildtype (GBM, WHO grade 4) is the most common malignant glioma of adults and is characterized by a severely hypoxic and immunosuppressive tumor microenvironment (TME). CLEC5A regulates immune responses in inflammatory and infectious diseases.… read more here.

Keywords: tam polarization; clec5a; pdpn; gbm ... See more keywords
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Elevated Expression of C-Type Lectin Domain Family 5-Member A (CLEC5A) and Its Relation to Inflammatory Parameters and Disease Course in Adult-Onset Still's Disease

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recommendations! Published in 2020 at "Journal of Immunology Research"

DOI: 10.1155/2020/9473497

Abstract: C-type lectin domain family 5-member A (CLEC5A) associates with adaptor DAP12 (DNAX activation protein 12) to form receptor complexes involved in inflammatory responses. We postulated a potential role of CLEC5A in the pathogenesis of adult-onset… read more here.

Keywords: levels clec5a; disease course; activity; expression ... See more keywords

Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response

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recommendations! Published in 2022 at "Journal of Immunology Research"

DOI: 10.1155/2022/9926305

Abstract: C-Type lectin receptor 5A (CLEC5A) is a spleen tyrosine kinase- (Syk-) coupled pattern recognition receptor expressed on myeloid cells and involved in the innate immune response to viral and bacterial infections. Activation of the CLEC5A… read more here.

Keywords: response; clec5a; activation; myeloid cells ... See more keywords

CLEC5A Activation in Inflammatory Monocytes: A Mechanism for Enhanced Adaptive Immunity Following COVID-19 mRNA Vaccination in a Preclinical Study

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recommendations! Published in 2025 at "Viruses"

DOI: 10.3390/v17091233

Abstract: Background: CLEC5A is a C-type lectin expressed by monocytes and neutrophils, playing an important role in innate immunity. Although it has been shown to interact with the spike protein of SARS-CoV-2, its role during vaccination… read more here.

Keywords: clec5a; immunity; clec5a expression; activation ... See more keywords