Synthesis, antiproliferative activity and SAR analysis of (-)-cleistenolide and analogues.
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DOI: 10.1016/j.ejmech.2020.112597
Abstract: A new, modified total synthesis of (-)-cleistenolide (1) and sixteen new analogues or derivatives was achieved starting from commercially available 1,2-O-isopropylidene-α-d-glucofuranose. The synthesis of 1 proceeds in six steps and 67% overall yield, using single-carbon… read more here.
Keywords: sar analysis; antiproliferative activity; synthesis; cleistenolide analogues ... See more keywords